Association of maternal chronic disease with risk of congenital heart disease in offspring

Hsin Hsu Chou, Meng Jiun Chiou, Fu Wen Liang, Lea Hua Chen, Tsung Hsueh Lu, Chung Yi Li

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Information about known risk factors for congenital heart disease is scarce. In this population-based study, we aimed to investigate the relation between maternal chronic disease and congenital heart disease in offspring. Methods: The study cohort consisted of 1 387 650 live births from 2004 to 2010. We identified chronic disease in mothers and mild and severe forms of congenital heart disease in their offspring from Taiwan's National Health Insurance medical claims. We used multivariable logistic regression analysis to assess the associations of all cases and specific types of congenital heart disease with various maternal chronic diseases. Results: For mothers with the following chronic diseases, the overall prevalence of congenital heart disease in their children was significantly higher than for mothers without these diseases: diabetes mellitus type 1 (adjusted odds ratio [OR] 2.32, 95% confidence interval [CI] 1.66-3.25), diabetes mellitus type 2 (adjusted OR 2.85, 95% CI 2.60-3.12), hypertension (adjusted OR 1.87, 95% CI 1.69-2.07), congenital heart defects (adjusted OR 3.05, 95% CI 2.45-3.80), anemia (adjusted OR 1.31, 95% CI 1.25-1.38), connective tissue disorders (adjusted OR 1.39, 95% CI 1.19-1.62), epilepsy (adjusted OR 1.37, 95% CI 1.08-1.74) and mood disorders (adjusted OR 1.25, 95% CI 1.11-1.41). The same pattern held for mild forms of congenital heart disease. A higher prevalence of severe congenital heart disease was seen only among offspring of mothers with congenital heart defects or type 2 diabetes. Interpretation: The children of women with several kinds of chronic disease appear to be at risk for congenital heart disease. Preconception counselling and optimum treatment of pregnant women with chronic disease would seem prudent.

Original languageEnglish
Pages (from-to)E438-E446
JournalCMAJ
Volume188
Issue number17-18
DOIs
Publication statusPublished - 2016 Dec 6

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Heart Diseases
Chronic Disease
Odds Ratio
Mothers
Confidence Intervals
Congenital Heart Defects
Type 2 Diabetes Mellitus
National Health Programs
Live Birth
Mood Disorders
Type 1 Diabetes Mellitus
Taiwan
Connective Tissue
Counseling
Anemia
Pregnant Women
Epilepsy
Cohort Studies
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chou, Hsin Hsu ; Chiou, Meng Jiun ; Liang, Fu Wen ; Chen, Lea Hua ; Lu, Tsung Hsueh ; Li, Chung Yi. / Association of maternal chronic disease with risk of congenital heart disease in offspring. In: CMAJ. 2016 ; Vol. 188, No. 17-18. pp. E438-E446.
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abstract = "Background: Information about known risk factors for congenital heart disease is scarce. In this population-based study, we aimed to investigate the relation between maternal chronic disease and congenital heart disease in offspring. Methods: The study cohort consisted of 1 387 650 live births from 2004 to 2010. We identified chronic disease in mothers and mild and severe forms of congenital heart disease in their offspring from Taiwan's National Health Insurance medical claims. We used multivariable logistic regression analysis to assess the associations of all cases and specific types of congenital heart disease with various maternal chronic diseases. Results: For mothers with the following chronic diseases, the overall prevalence of congenital heart disease in their children was significantly higher than for mothers without these diseases: diabetes mellitus type 1 (adjusted odds ratio [OR] 2.32, 95{\%} confidence interval [CI] 1.66-3.25), diabetes mellitus type 2 (adjusted OR 2.85, 95{\%} CI 2.60-3.12), hypertension (adjusted OR 1.87, 95{\%} CI 1.69-2.07), congenital heart defects (adjusted OR 3.05, 95{\%} CI 2.45-3.80), anemia (adjusted OR 1.31, 95{\%} CI 1.25-1.38), connective tissue disorders (adjusted OR 1.39, 95{\%} CI 1.19-1.62), epilepsy (adjusted OR 1.37, 95{\%} CI 1.08-1.74) and mood disorders (adjusted OR 1.25, 95{\%} CI 1.11-1.41). The same pattern held for mild forms of congenital heart disease. A higher prevalence of severe congenital heart disease was seen only among offspring of mothers with congenital heart defects or type 2 diabetes. Interpretation: The children of women with several kinds of chronic disease appear to be at risk for congenital heart disease. Preconception counselling and optimum treatment of pregnant women with chronic disease would seem prudent.",
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Association of maternal chronic disease with risk of congenital heart disease in offspring. / Chou, Hsin Hsu; Chiou, Meng Jiun; Liang, Fu Wen; Chen, Lea Hua; Lu, Tsung Hsueh; Li, Chung Yi.

In: CMAJ, Vol. 188, No. 17-18, 06.12.2016, p. E438-E446.

Research output: Contribution to journalArticle

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AU - Chou, Hsin Hsu

AU - Chiou, Meng Jiun

AU - Liang, Fu Wen

AU - Chen, Lea Hua

AU - Lu, Tsung Hsueh

AU - Li, Chung Yi

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N2 - Background: Information about known risk factors for congenital heart disease is scarce. In this population-based study, we aimed to investigate the relation between maternal chronic disease and congenital heart disease in offspring. Methods: The study cohort consisted of 1 387 650 live births from 2004 to 2010. We identified chronic disease in mothers and mild and severe forms of congenital heart disease in their offspring from Taiwan's National Health Insurance medical claims. We used multivariable logistic regression analysis to assess the associations of all cases and specific types of congenital heart disease with various maternal chronic diseases. Results: For mothers with the following chronic diseases, the overall prevalence of congenital heart disease in their children was significantly higher than for mothers without these diseases: diabetes mellitus type 1 (adjusted odds ratio [OR] 2.32, 95% confidence interval [CI] 1.66-3.25), diabetes mellitus type 2 (adjusted OR 2.85, 95% CI 2.60-3.12), hypertension (adjusted OR 1.87, 95% CI 1.69-2.07), congenital heart defects (adjusted OR 3.05, 95% CI 2.45-3.80), anemia (adjusted OR 1.31, 95% CI 1.25-1.38), connective tissue disorders (adjusted OR 1.39, 95% CI 1.19-1.62), epilepsy (adjusted OR 1.37, 95% CI 1.08-1.74) and mood disorders (adjusted OR 1.25, 95% CI 1.11-1.41). The same pattern held for mild forms of congenital heart disease. A higher prevalence of severe congenital heart disease was seen only among offspring of mothers with congenital heart defects or type 2 diabetes. Interpretation: The children of women with several kinds of chronic disease appear to be at risk for congenital heart disease. Preconception counselling and optimum treatment of pregnant women with chronic disease would seem prudent.

AB - Background: Information about known risk factors for congenital heart disease is scarce. In this population-based study, we aimed to investigate the relation between maternal chronic disease and congenital heart disease in offspring. Methods: The study cohort consisted of 1 387 650 live births from 2004 to 2010. We identified chronic disease in mothers and mild and severe forms of congenital heart disease in their offspring from Taiwan's National Health Insurance medical claims. We used multivariable logistic regression analysis to assess the associations of all cases and specific types of congenital heart disease with various maternal chronic diseases. Results: For mothers with the following chronic diseases, the overall prevalence of congenital heart disease in their children was significantly higher than for mothers without these diseases: diabetes mellitus type 1 (adjusted odds ratio [OR] 2.32, 95% confidence interval [CI] 1.66-3.25), diabetes mellitus type 2 (adjusted OR 2.85, 95% CI 2.60-3.12), hypertension (adjusted OR 1.87, 95% CI 1.69-2.07), congenital heart defects (adjusted OR 3.05, 95% CI 2.45-3.80), anemia (adjusted OR 1.31, 95% CI 1.25-1.38), connective tissue disorders (adjusted OR 1.39, 95% CI 1.19-1.62), epilepsy (adjusted OR 1.37, 95% CI 1.08-1.74) and mood disorders (adjusted OR 1.25, 95% CI 1.11-1.41). The same pattern held for mild forms of congenital heart disease. A higher prevalence of severe congenital heart disease was seen only among offspring of mothers with congenital heart defects or type 2 diabetes. Interpretation: The children of women with several kinds of chronic disease appear to be at risk for congenital heart disease. Preconception counselling and optimum treatment of pregnant women with chronic disease would seem prudent.

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