TY - JOUR
T1 - Association of monoamine oxidase A (MAOA) polymorphisms and clinical subgroups of major depressive disorders in the Han Chinese population
AU - Huang, San Yuan
AU - Lin, Ming Teng
AU - Lin, Wei Wen
AU - Huang, Cheng Chang
AU - Shy, Mee Jen
AU - Lu, Ru Band
N1 - Funding Information:
This study was supported in part by National Science Council Grants NSC94-2314-B-016-016, NSC95-2314-B-016-019 (SYH); by the Department of Health Grants DOH94-TD-D-113-040, DOH96-TD-D-113-031 (SYH); by Tri-Service General Hospital Grant TSGH-C92-66, TSGH-C94-76 (SYH). The authors thank Miss Fan-Yi Lin and Mr Fu-Kuei Chang for their assistance in the preparation of the manuscript.
PY - 2009
Y1 - 2009
N2 - It has been proposed that an MAOA abnormality may be an important factor in the development of major depressive disorder (MDD). Various polymorphisms of the MAOA gene have been investigated for possible associations with mood disorders, but results have been inconsistent. The goal of the present study was to investigate whether polymorphisms of the MAOA gene are associated with MDD or alternatively with different clinical subgroups of MDD. A total of 590 Han Chinese subjects in Taiwan (312 controls and 278 MDD patients) were recruited. Among the males, there were no associations with MAOA polymorphisms. Among the females, an association was found between MAOA polymorphisms and severe MDD (P=0.041 for uVNTR and 0.017 for EcoRV (rs1137070), respectively). However, in analyses of haplotype frequencies and multiple logistic regression, MAOA polymorphisms were not associated with either MDD or its subgroups. The results suggest that MAOA polymorphisms do not play a major role in the pathogenesis of MDD or its subgroups. However, a potential role for a minor association with some specific subgroups and with different ethnic samples needs to be explored further.
AB - It has been proposed that an MAOA abnormality may be an important factor in the development of major depressive disorder (MDD). Various polymorphisms of the MAOA gene have been investigated for possible associations with mood disorders, but results have been inconsistent. The goal of the present study was to investigate whether polymorphisms of the MAOA gene are associated with MDD or alternatively with different clinical subgroups of MDD. A total of 590 Han Chinese subjects in Taiwan (312 controls and 278 MDD patients) were recruited. Among the males, there were no associations with MAOA polymorphisms. Among the females, an association was found between MAOA polymorphisms and severe MDD (P=0.041 for uVNTR and 0.017 for EcoRV (rs1137070), respectively). However, in analyses of haplotype frequencies and multiple logistic regression, MAOA polymorphisms were not associated with either MDD or its subgroups. The results suggest that MAOA polymorphisms do not play a major role in the pathogenesis of MDD or its subgroups. However, a potential role for a minor association with some specific subgroups and with different ethnic samples needs to be explored further.
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U2 - 10.1080/15622970701816506
DO - 10.1080/15622970701816506
M3 - Article
C2 - 19224413
AN - SCOPUS:77449133090
SN - 1562-2975
VL - 10
SP - 544
EP - 551
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
IS - 4 PART 2
ER -
