Association of nonsynonymous substitutions in the intermediate region of the vacA gene of helicobacter pylori with gastric diseases in Taiwan

Shew Meei Sheu, Kuei Hsiang Hung, Bor-Shyang Sheu, Hsiao Bai Yang, Jiunn Jong Wu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGIT SSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the il-type cluster C sequence could be a marker of VacA in the Taiwanese strains.

Original languageEnglish
Pages (from-to)249-251
Number of pages3
JournalJournal of Clinical Microbiology
Volume47
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Stomach Diseases
Taiwan
Helicobacter pylori
Amino Acid Sequence
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

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Association of nonsynonymous substitutions in the intermediate region of the vacA gene of helicobacter pylori with gastric diseases in Taiwan. / Sheu, Shew Meei; Hung, Kuei Hsiang; Sheu, Bor-Shyang; Yang, Hsiao Bai; Wu, Jiunn Jong.

In: Journal of Clinical Microbiology, Vol. 47, No. 1, 01.01.2009, p. 249-251.

Research output: Contribution to journalArticle

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