Association of nonsynonymous substitutions in the intermediate region of the vacA gene of helicobacter pylori with gastric diseases in Taiwan

Shew Meei Sheu, Kuei Hsiang Hung, Bor Shyang Sheu, Hsiao Bai Yang, Jiunn Jong Wu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGIT SSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the il-type cluster C sequence could be a marker of VacA in the Taiwanese strains.

Original languageEnglish
Pages (from-to)249-251
Number of pages3
JournalJournal of Clinical Microbiology
Volume47
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

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