Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population

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Abstract

Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalJournal of assisted reproduction and genetics
Volume28
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

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Progesterone Receptors
Pregnancy
Population
Single Nucleotide Polymorphism
Progesterone
Menstruation
Luteal Phase
Gene Frequency
Haplotypes
Placenta
Genes
Oocytes
Genotype
Maintenance

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

Cite this

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title = "Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population",
abstract = "Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.",
author = "Mei-Tsz Su and Lee, {I. Wen} and Yi-Chi Chen and Pao-Lin Kuo",
year = "2011",
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day = "1",
doi = "10.1007/s10815-010-9510-8",
language = "English",
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journal = "Journal of Assisted Reproduction and Genetics",
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AU - Su, Mei-Tsz

AU - Lee, I. Wen

AU - Chen, Yi-Chi

AU - Kuo, Pao-Lin

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.

AB - Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.

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