TY - JOUR
T1 - Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population
AU - Su, Mei Tsz
AU - Lee, I. Wen
AU - Chen, Yi Chi
AU - Kuo, Pao Lin
N1 - Funding Information:
Acknowledgements This study was supported by an intramural grant from National Cheng-Kung University Hospital (NCKH-9702035).
Funding Information:
Financial support This study was supported by an intramural grant from National Cheng-Kung University Hospital (NCKH-9702035).
PY - 2011/3
Y1 - 2011/3
N2 - Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.
AB - Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.
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U2 - 10.1007/s10815-010-9510-8
DO - 10.1007/s10815-010-9510-8
M3 - Article
C2 - 21086036
AN - SCOPUS:79958286143
VL - 28
SP - 239
EP - 243
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
SN - 1058-0468
IS - 3
ER -