Abstract
Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.
| Original language | English |
|---|---|
| Pages (from-to) | 239-243 |
| Number of pages | 5 |
| Journal | Journal of assisted reproduction and genetics |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2011 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Obstetrics and Gynaecology
- Reproductive Medicine
- Developmental Biology
- Genetics
- Genetics(clinical)
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Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population. / Su, Mei-Tsz; Lee, I. Wen; Chen, Yi-Chi; Kuo, Pao-Lin.
In: Journal of assisted reproduction and genetics, Vol. 28, No. 3, 01.03.2011, p. 239-243.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population
AU - Su, Mei-Tsz
AU - Lee, I. Wen
AU - Chen, Yi-Chi
AU - Kuo, Pao-Lin
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.
AB - Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values∈=∈0.006). In addition, the C-C haplotype, which consists of rs590688C∈>∈G and rs11224592T∈>∈C, is associated with a decreased risk of RPL (p∈=∈0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.
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U2 - 10.1007/s10815-010-9510-8
DO - 10.1007/s10815-010-9510-8
M3 - Article
VL - 28
SP - 239
EP - 243
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
SN - 1058-0468
IS - 3
ER -