TY - JOUR
T1 - Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese
AU - Huang, San Yuan
AU - Chen, Hsing Kang
AU - Ma, Kuo Hsing
AU - Shy, Mee Jen
AU - Chen, Jiun Hsiung
AU - Lin, Wen chi
AU - Lu, Ru Band
N1 - Funding Information:
This study was supported in part by the National Science Council grants NSC95-2314-B-016-019-MY2 and NSC 97-2314-B-016-001-MY2 (S.Y.H); by the Department of Health grant DOH94-TD-D-113-040 (S.Y.H); and by the Tri-Service General Hospital and National Defense Medical Center grants TSGH-C97-88 , TSGH-C98-8 , and 97 T26-06 (S.Y.H). The authors thank Miss. Fan-Yi Lin, Mr. Cheng-Chang Huang for their assistance in the preparation and proof-reading of this manuscript.
Funding Information:
Funding for this study was provided in part by National Science Council grants; by the Department of Health grants; and by Tri-Service General Hospital and National Defense Medical Center grant. Study sponsors had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2010/1
Y1 - 2010/1
N2 - Objective: Although dopamine was implicated in the etiology of schizophrenia, the human dopamine transporter gene (DAT1; SLC6A3) has not consistently been associated with schizophrenia. The purpose of this study was to examine whether six polymorphisms within the DAT1 gene are associated with schizophrenia. Methods: Six polymorphisms of the DAT1 gene (3 SNPs [rs6413429, rs2652511, and rs2975226] in the promoter region, one SNP [rs6347] in exon 9, and one SNP [rs27072]/one variable number tandem repeat [VNTR] in exon 15) were analyzed in 352 Chinese patients with schizophrenia and in 311 healthy controls. Pretreatment psychopathology was assessed using the Positive and Negative Syndrome Scale in a subset of 160 hospitalized schizophrenia patients who were drug-free or drug-naïve. Results: A statistically significant difference in two polymorphisms (rs2652511 and rs2975226) and a promoter region haplotype (rs2652511, rs2975226, and rs6413429) was found between patients and healthy controls. No association with schizophrenia was found for other polymorphisms and another haplotype (3′ region). Symptoms severity (PANSS global, positive, negative and general symptoms scores) was similar regardless of DAT1 polymorphism. Conclusion: The promoter region of the DAT1 gene may play a role in increasing susceptibility to schizophrenia, but does not affect the severity of psychotic symptoms in Han Chinese. Crown
AB - Objective: Although dopamine was implicated in the etiology of schizophrenia, the human dopamine transporter gene (DAT1; SLC6A3) has not consistently been associated with schizophrenia. The purpose of this study was to examine whether six polymorphisms within the DAT1 gene are associated with schizophrenia. Methods: Six polymorphisms of the DAT1 gene (3 SNPs [rs6413429, rs2652511, and rs2975226] in the promoter region, one SNP [rs6347] in exon 9, and one SNP [rs27072]/one variable number tandem repeat [VNTR] in exon 15) were analyzed in 352 Chinese patients with schizophrenia and in 311 healthy controls. Pretreatment psychopathology was assessed using the Positive and Negative Syndrome Scale in a subset of 160 hospitalized schizophrenia patients who were drug-free or drug-naïve. Results: A statistically significant difference in two polymorphisms (rs2652511 and rs2975226) and a promoter region haplotype (rs2652511, rs2975226, and rs6413429) was found between patients and healthy controls. No association with schizophrenia was found for other polymorphisms and another haplotype (3′ region). Symptoms severity (PANSS global, positive, negative and general symptoms scores) was similar regardless of DAT1 polymorphism. Conclusion: The promoter region of the DAT1 gene may play a role in increasing susceptibility to schizophrenia, but does not affect the severity of psychotic symptoms in Han Chinese. Crown
UR - http://www.scopus.com/inward/record.url?scp=71649102773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71649102773&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2009.10.004
DO - 10.1016/j.schres.2009.10.004
M3 - Article
C2 - 19879111
AN - SCOPUS:71649102773
SN - 0920-9964
VL - 116
SP - 68
EP - 74
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -
