Association of single nucleotide polymorphisms of MD-1 gene with pediatric and adult asthma in the Taiwanese population

Shih Wei Lee, Jiu-Yao Wang, Yuan Chun Hsieh, Ying Jye Wu, Hsien Wei Ting, Lawrence Shih Hsin Wu

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5 Citations (Scopus)

Abstract

Background and Purpose: MD-1 (myeloid differentiation 1; also known as Ly86, lymphocyte antigen 86), interacting with radioprotective 105, plays an important role in the Toll-like receptor 4 signaling pathway. It has been suggested that MD-1 is involved in the development of inflammation and atopic diseases. The purpose of this study was to investigate the genetic association of single nucleotide polymorphisms (SNPs) of MD-1 and asthma in the Taiwanese population. Methods: Genotyping 34 SNPs in the MD-1 gene region was performed in a case-control study involving 281 children with asthma and 237 controls. A further 309 children and adults were genotyped for the SNP rs7740529 only, for validation of an identified association. Results: In intron 1, we identified an SNP, rs7740529, which is associated with asthma in Taiwanese children (p=0.0358). Inclusion of a further 309 subjects increased the significance of the association (p=0.0093), and also demonstrated that rs7740529 is associated with adult asthma. The TT genotype confers risk of both pediatric and adult asthma. Conclusion: These results suggest that MD-1 could be a susceptible gene for asthma in the Taiwanese population.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalJournal of Microbiology, Immunology and Infection
Volume41
Issue number6
Publication statusPublished - 2008 Dec 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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