Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese

Ming Chuan Hu, Sheng Yu Lee, Tzu Yun Wang, Shiou Lan Chen, Yun Hsuan Chang, Shih Heng Chen, Chun Hsien Chu, Chen Lin Wang, I. Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru Band Lu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background: Several studies have hypothesized that genes involved in the dopamine system, including dopamine type-2 receptor (DRD2)-related TaqIA polymorphism and monoamine oxidase-A upstream variable number tandem repeat (uVNTR), may be associated with alcoholism. But their results were contradictory because of alcoholism's heterogeneity. Therefore, we examined whether the DRD2TaqIA and MAOA-uVNTR gene polymorphisms are susceptibility factors for alcoholism comorbid with bipolar disorder (ALC. +. BP) in Han Chinese in Taiwan. Methods: We recruited 101 Han Chinese men with comorbid alcoholism and bipolar disorder, and 328 healthy male controls from the community. Genotyping was done using PCR-RFLP. Results: There were no significant differences in the genotypic frequencies of the DRD2TaqIA or the MAOA-uVNTR polymorphisms between the 2 groups. The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC. +. BP (odds ratio = 0.432, p= 0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC. +. BP (odds ratio = 3.451, p= 0.018). Conclusions: We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC. +. BP.

Original languageEnglish
Pages (from-to)144-148
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number1
Publication statusPublished - 2013 Jan

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry


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