Associations between maternal phthalate exposure and cord sex hormones in human infants

Lung Cheng Lin; Shu Li Wang; Yu Chen Chang; Po Chin Huang; Joan Tin Cheng; Pen Hua Su; Pao Chi Liao

doi:10.1016/j.chemosphere.2010.12.079

Associations between maternal phthalate exposure and cord sex hormones in human infants

Lung Cheng Lin, Shu Li Wang, Yu Chen Chang, Po Chin Huang, Joan Tin Cheng, Pen Hua Su, Pao Chi Liao

Department of Environmental and Occupational Health

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

It has been speculated that maternal phthalate exposure may affect reproductive development in human newborns. However, the mechanism awaits further investigation. The aim is to evaluate the association between maternal phthalate exposure and cord sex steroid hormones in pregnant women and their newborns from the general population. A total of 155 maternal and infant pair were recruited and analyzed. Levels of urinary phthalate metabolites and sex steroid hormones were determined using liquid chromatography/electrospray tandem mass spectrometry (LC-ESI-MS/MS) and radioimmunoassay (RIA), respectively. No significant correlation was found between each steroid hormones and phthalate metabolites for male newborns, except MMP was marginally significantly correlated with E₂. After adjusting for maternal age, estradiol (E₂) levels in cord serum from male newborns were not correlated with maternal urinary phthalate metabolites. In female newborns, the maternal urinary levels of mono-(2-ethylhexyl) phthalate (MEHP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP) were negatively correlated with the free testosterone (fT) and fT/E₂ levels in cord serum with Pearson correlation coefficients ranging between -0.24 and -0.29 (p<0.05). Additionally, after gestational age was adjusted, the maternal urinary level of DEHP was negatively correlated with the free testosterone (fT) and fT/E₂ levels in cord serum. We suggest that maternal exposure to phthalates may affect sex steroid hormones status in fetal and newborn stage.

Original language	English
Pages (from-to)	1192-1199
Number of pages	8
Journal	Chemosphere
Volume	83
Issue number	8
DOIs	https://doi.org/10.1016/j.chemosphere.2010.12.079
Publication status	Published - 2011 May

All Science Journal Classification (ASJC) codes

Environmental Engineering
Chemistry(all)
Environmental Chemistry
Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

Access to Document

10.1016/j.chemosphere.2010.12.079

Cite this

@article{5c53cdad614f4428bdd52f3e349fbc58,

title = "Associations between maternal phthalate exposure and cord sex hormones in human infants",

abstract = "It has been speculated that maternal phthalate exposure may affect reproductive development in human newborns. However, the mechanism awaits further investigation. The aim is to evaluate the association between maternal phthalate exposure and cord sex steroid hormones in pregnant women and their newborns from the general population. A total of 155 maternal and infant pair were recruited and analyzed. Levels of urinary phthalate metabolites and sex steroid hormones were determined using liquid chromatography/electrospray tandem mass spectrometry (LC-ESI-MS/MS) and radioimmunoassay (RIA), respectively. No significant correlation was found between each steroid hormones and phthalate metabolites for male newborns, except MMP was marginally significantly correlated with E2. After adjusting for maternal age, estradiol (E2) levels in cord serum from male newborns were not correlated with maternal urinary phthalate metabolites. In female newborns, the maternal urinary levels of mono-(2-ethylhexyl) phthalate (MEHP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP) were negatively correlated with the free testosterone (fT) and fT/E2 levels in cord serum with Pearson correlation coefficients ranging between -0.24 and -0.29 (p<0.05). Additionally, after gestational age was adjusted, the maternal urinary level of DEHP was negatively correlated with the free testosterone (fT) and fT/E2 levels in cord serum. We suggest that maternal exposure to phthalates may affect sex steroid hormones status in fetal and newborn stage.",

author = "Lin, {Lung Cheng} and Wang, {Shu Li} and Chang, {Yu Chen} and Huang, {Po Chin} and Cheng, {Joan Tin} and Su, {Pen Hua} and Liao, {Pao Chi}",

note = "Funding Information: This work was supported by Grants NSC94-2113-M006-06 and NSC97-2113-M-006-005-MY3 from National Science Council, Taiwan, and Grants EO-097-PP-05 and EO-098-PP-03 from National Health Research Institutes, Taiwan. ",

year = "2011",

month = may,

doi = "10.1016/j.chemosphere.2010.12.079",

language = "English",

volume = "83",

pages = "1192--1199",

journal = "Chemosphere",

issn = "0045-6535",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Associations between maternal phthalate exposure and cord sex hormones in human infants

AU - Lin, Lung Cheng

AU - Wang, Shu Li

AU - Chang, Yu Chen

AU - Huang, Po Chin

AU - Cheng, Joan Tin

AU - Su, Pen Hua

AU - Liao, Pao Chi

N1 - Funding Information: This work was supported by Grants NSC94-2113-M006-06 and NSC97-2113-M-006-005-MY3 from National Science Council, Taiwan, and Grants EO-097-PP-05 and EO-098-PP-03 from National Health Research Institutes, Taiwan.

PY - 2011/5

Y1 - 2011/5

N2 - It has been speculated that maternal phthalate exposure may affect reproductive development in human newborns. However, the mechanism awaits further investigation. The aim is to evaluate the association between maternal phthalate exposure and cord sex steroid hormones in pregnant women and their newborns from the general population. A total of 155 maternal and infant pair were recruited and analyzed. Levels of urinary phthalate metabolites and sex steroid hormones were determined using liquid chromatography/electrospray tandem mass spectrometry (LC-ESI-MS/MS) and radioimmunoassay (RIA), respectively. No significant correlation was found between each steroid hormones and phthalate metabolites for male newborns, except MMP was marginally significantly correlated with E2. After adjusting for maternal age, estradiol (E2) levels in cord serum from male newborns were not correlated with maternal urinary phthalate metabolites. In female newborns, the maternal urinary levels of mono-(2-ethylhexyl) phthalate (MEHP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP) were negatively correlated with the free testosterone (fT) and fT/E2 levels in cord serum with Pearson correlation coefficients ranging between -0.24 and -0.29 (p<0.05). Additionally, after gestational age was adjusted, the maternal urinary level of DEHP was negatively correlated with the free testosterone (fT) and fT/E2 levels in cord serum. We suggest that maternal exposure to phthalates may affect sex steroid hormones status in fetal and newborn stage.

AB - It has been speculated that maternal phthalate exposure may affect reproductive development in human newborns. However, the mechanism awaits further investigation. The aim is to evaluate the association between maternal phthalate exposure and cord sex steroid hormones in pregnant women and their newborns from the general population. A total of 155 maternal and infant pair were recruited and analyzed. Levels of urinary phthalate metabolites and sex steroid hormones were determined using liquid chromatography/electrospray tandem mass spectrometry (LC-ESI-MS/MS) and radioimmunoassay (RIA), respectively. No significant correlation was found between each steroid hormones and phthalate metabolites for male newborns, except MMP was marginally significantly correlated with E2. After adjusting for maternal age, estradiol (E2) levels in cord serum from male newborns were not correlated with maternal urinary phthalate metabolites. In female newborns, the maternal urinary levels of mono-(2-ethylhexyl) phthalate (MEHP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP) were negatively correlated with the free testosterone (fT) and fT/E2 levels in cord serum with Pearson correlation coefficients ranging between -0.24 and -0.29 (p<0.05). Additionally, after gestational age was adjusted, the maternal urinary level of DEHP was negatively correlated with the free testosterone (fT) and fT/E2 levels in cord serum. We suggest that maternal exposure to phthalates may affect sex steroid hormones status in fetal and newborn stage.

UR - http://www.scopus.com/inward/record.url?scp=79955041499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955041499&partnerID=8YFLogxK

U2 - 10.1016/j.chemosphere.2010.12.079

DO - 10.1016/j.chemosphere.2010.12.079

M3 - Article

C2 - 21272909

AN - SCOPUS:79955041499

VL - 83

SP - 1192

EP - 1199

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 8

ER -

Associations between maternal phthalate exposure and cord sex hormones in human infants

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this