Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy

Liu Chun Wang; Li Chan Chang; Wen Qi Chen; Yi Hsin Chien; Po Ya Chang; Chih Wen Pao; Yin Fen Liu; Hwo Shuenn Sheu; Wen Pin Su; Chen Hao Yeh; Chen Sheng Yeh

doi:10.1038/s41467-022-35515-8

Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy

Liu Chun Wang, Li Chan Chang, Wen Qi Chen, Yi Hsin Chien, Po Ya Chang, Chih Wen Pao, Yin Fen Liu, Hwo Shuenn Sheu, Wen Pin Su, Chen Hao Yeh, Chen Sheng Yeh

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Abstract

Herein, we employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatments on female mice. Controlling the addition of precursor HAuCl₄ allows for the fabrication of different atomic ratios of Au_xCu_y. X-ray absorption near edge spectra indicates that Au and Cu are the predominant oxidation states of zero valence. This suggests that the charges of Au and Cu remain unchanged after galvanic replacement. Specifically, Au_0.02Cu_0.98 composition reveals the enhanced •OH generation following O₂ → H₂O₂ → •OH. The degradable Au_0.02Cu_0.98 released Cu⁺ and Cu²⁺ resulting in oxygen reduction and Fenton-like reactions. Simulation studies indicate that Au single atoms boot zero-valent copper to reveal the catalytic capability of Au_0.02Cu_0.98 for O₂ → H₂O₂ → •OH as well. Instead of using endogenous H₂O₂, H₂O₂ can be sourced from the O₂ in the air through the use of nanocubes. Notably, the Au_0.02Cu_0.98 structure is degradable and renal-clearable.

Original language	English
Article number	7772
Journal	Nature communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-35515-8
Publication status	Published - 2022 Dec

All Science Journal Classification (ASJC) codes

General Physics and Astronomy
General Chemistry
General Biochemistry,Genetics and Molecular Biology

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10.1038/s41467-022-35515-8

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Wang, L. C., Chang, L. C., Chen, W. Q., Chien, Y. H., Chang, P. Y., Pao, C. W., Liu, Y. F., Sheu, H. S., Su, W. P., Yeh, C. H., & Yeh, C. S. (2022). Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy. Nature communications, 13(1), Article 7772. https://doi.org/10.1038/s41467-022-35515-8

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title = "Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy",

abstract = "Herein, we employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatments on female mice. Controlling the addition of precursor HAuCl4 allows for the fabrication of different atomic ratios of AuxCuy. X-ray absorption near edge spectra indicates that Au and Cu are the predominant oxidation states of zero valence. This suggests that the charges of Au and Cu remain unchanged after galvanic replacement. Specifically, Au0.02Cu0.98 composition reveals the enhanced •OH generation following O2 → H2O2 → •OH. The degradable Au0.02Cu0.98 released Cu+ and Cu2+ resulting in oxygen reduction and Fenton-like reactions. Simulation studies indicate that Au single atoms boot zero-valent copper to reveal the catalytic capability of Au0.02Cu0.98 for O2 → H2O2 → •OH as well. Instead of using endogenous H2O2, H2O2 can be sourced from the O2 in the air through the use of nanocubes. Notably, the Au0.02Cu0.98 structure is degradable and renal-clearable.",

author = "Wang, {Liu Chun} and Chang, {Li Chan} and Chen, {Wen Qi} and Chien, {Yi Hsin} and Chang, {Po Ya} and Pao, {Chih Wen} and Liu, {Yin Fen} and Sheu, {Hwo Shuenn} and Su, {Wen Pin} and Yeh, {Chen Hao} and Yeh, {Chen Sheng}",

note = "Funding Information: C.-S.Y. appreciates the financial support provided by the Ministry of Science and Technology, Taiwan (109-2113-M-006-011-MY3). W.-P.S. appreciates the financial support provided by the Ministry of Science and Technology or National Science and Technology Council, Taiwan (109-2314-B-006-084-MY3; 111-2321-B-006-011; 111-2314-B-006-004). Y.-H.C. appreciate the financial support provided by the Ministry of Science and Technology, Taiwan (MOST 111-2113-M-035-003-MY2). H.-S.S. appreciates the TLS 01C1 and TPS44A beamline stuffs Dr. Ting-Shan Chan, Dr. Tai-Sing Wu, Dr. Jeng-Lung Chen for their helps in XAS data collection. C.-H.Y. appreciates the financial support provided by the Ministry of Science and Technology, Taiwan (109-2113-M-035-003-MY3). Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-022-35515-8",

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volume = "13",

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T1 - Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy

AU - Wang, Liu Chun

AU - Chang, Li Chan

AU - Chen, Wen Qi

AU - Chien, Yi Hsin

AU - Chang, Po Ya

AU - Pao, Chih Wen

AU - Liu, Yin Fen

AU - Sheu, Hwo Shuenn

AU - Su, Wen Pin

AU - Yeh, Chen Hao

AU - Yeh, Chen Sheng

N1 - Funding Information: C.-S.Y. appreciates the financial support provided by the Ministry of Science and Technology, Taiwan (109-2113-M-006-011-MY3). W.-P.S. appreciates the financial support provided by the Ministry of Science and Technology or National Science and Technology Council, Taiwan (109-2314-B-006-084-MY3; 111-2321-B-006-011; 111-2314-B-006-004). Y.-H.C. appreciate the financial support provided by the Ministry of Science and Technology, Taiwan (MOST 111-2113-M-035-003-MY2). H.-S.S. appreciates the TLS 01C1 and TPS44A beamline stuffs Dr. Ting-Shan Chan, Dr. Tai-Sing Wu, Dr. Jeng-Lung Chen for their helps in XAS data collection. C.-H.Y. appreciates the financial support provided by the Ministry of Science and Technology, Taiwan (109-2113-M-035-003-MY3). Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Herein, we employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatments on female mice. Controlling the addition of precursor HAuCl4 allows for the fabrication of different atomic ratios of AuxCuy. X-ray absorption near edge spectra indicates that Au and Cu are the predominant oxidation states of zero valence. This suggests that the charges of Au and Cu remain unchanged after galvanic replacement. Specifically, Au0.02Cu0.98 composition reveals the enhanced •OH generation following O2 → H2O2 → •OH. The degradable Au0.02Cu0.98 released Cu+ and Cu2+ resulting in oxygen reduction and Fenton-like reactions. Simulation studies indicate that Au single atoms boot zero-valent copper to reveal the catalytic capability of Au0.02Cu0.98 for O2 → H2O2 → •OH as well. Instead of using endogenous H2O2, H2O2 can be sourced from the O2 in the air through the use of nanocubes. Notably, the Au0.02Cu0.98 structure is degradable and renal-clearable.

AB - Herein, we employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatments on female mice. Controlling the addition of precursor HAuCl4 allows for the fabrication of different atomic ratios of AuxCuy. X-ray absorption near edge spectra indicates that Au and Cu are the predominant oxidation states of zero valence. This suggests that the charges of Au and Cu remain unchanged after galvanic replacement. Specifically, Au0.02Cu0.98 composition reveals the enhanced •OH generation following O2 → H2O2 → •OH. The degradable Au0.02Cu0.98 released Cu+ and Cu2+ resulting in oxygen reduction and Fenton-like reactions. Simulation studies indicate that Au single atoms boot zero-valent copper to reveal the catalytic capability of Au0.02Cu0.98 for O2 → H2O2 → •OH as well. Instead of using endogenous H2O2, H2O2 can be sourced from the O2 in the air through the use of nanocubes. Notably, the Au0.02Cu0.98 structure is degradable and renal-clearable.

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ER -

Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy

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