Attachment and proliferation of neonatal rat calvarial osteoblasts on Ti6Al4V: Effect of surface chemistries of the alloy

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

This study examined the cell attachment and proliferation of neonatal rat calvarial osteoblasts on Ti6Al4V alloy as affected by the surface modifications. The modifications could alter simultaneously the surface chemistries of the alloy (elemental difference of Ti, Al, V, Cu and Ni about 300-600μm thick examined by EDS) as well as the XPS nano-surface characteristics of oxides on the metal surface (chemistries of oxides, amphoteric OH group adsorbed on oxides, and oxide thickness). Three materials including two from modifications and a control were examined. It is argued that a slight change of the nano-surface characteristics of oxides as a result of the modifications neither alters the in vitro capability of Ca and P ion adsorption nor affects the metal ion dissolution behavior of the alloy. This implies that any influence on the cytocompatibility of the materials should only be correlated to the effect of surface chemistries of the alloy and the associated metal ion dissolution behavior of the alloy. The experimental results suggest that the cell response of neonatal rat calvarial osteoblasts on the Ti6Al4V alloy should neither be affected by the variation of surface chemistries of the alloy in a range studied.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalBiomaterials
Volume25
Issue number1
DOIs
Publication statusPublished - 2004 Jan 1

Fingerprint

Osteoblasts
Surface chemistry
Rats
Oxides
Metals
Ions
Metal ions
Dissolution
titanium alloy (TiAl6V4)
Adsorption
Surface treatment
Energy dispersive spectroscopy
X ray photoelectron spectroscopy
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

@article{bdd7054cf2634b9caf0d503d19b7ff78,
title = "Attachment and proliferation of neonatal rat calvarial osteoblasts on Ti6Al4V: Effect of surface chemistries of the alloy",
abstract = "This study examined the cell attachment and proliferation of neonatal rat calvarial osteoblasts on Ti6Al4V alloy as affected by the surface modifications. The modifications could alter simultaneously the surface chemistries of the alloy (elemental difference of Ti, Al, V, Cu and Ni about 300-600μm thick examined by EDS) as well as the XPS nano-surface characteristics of oxides on the metal surface (chemistries of oxides, amphoteric OH group adsorbed on oxides, and oxide thickness). Three materials including two from modifications and a control were examined. It is argued that a slight change of the nano-surface characteristics of oxides as a result of the modifications neither alters the in vitro capability of Ca and P ion adsorption nor affects the metal ion dissolution behavior of the alloy. This implies that any influence on the cytocompatibility of the materials should only be correlated to the effect of surface chemistries of the alloy and the associated metal ion dissolution behavior of the alloy. The experimental results suggest that the cell response of neonatal rat calvarial osteoblasts on the Ti6Al4V alloy should neither be affected by the variation of surface chemistries of the alloy in a range studied.",
author = "Lee, {T. M.} and E. Chang and Yang, {C. Y.}",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/S0142-9612(03)00465-4",
language = "English",
volume = "25",
pages = "23--32",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",
number = "1",

}

Attachment and proliferation of neonatal rat calvarial osteoblasts on Ti6Al4V : Effect of surface chemistries of the alloy. / Lee, T. M.; Chang, E.; Yang, C. Y.

In: Biomaterials, Vol. 25, No. 1, 01.01.2004, p. 23-32.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Attachment and proliferation of neonatal rat calvarial osteoblasts on Ti6Al4V

T2 - Effect of surface chemistries of the alloy

AU - Lee, T. M.

AU - Chang, E.

AU - Yang, C. Y.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - This study examined the cell attachment and proliferation of neonatal rat calvarial osteoblasts on Ti6Al4V alloy as affected by the surface modifications. The modifications could alter simultaneously the surface chemistries of the alloy (elemental difference of Ti, Al, V, Cu and Ni about 300-600μm thick examined by EDS) as well as the XPS nano-surface characteristics of oxides on the metal surface (chemistries of oxides, amphoteric OH group adsorbed on oxides, and oxide thickness). Three materials including two from modifications and a control were examined. It is argued that a slight change of the nano-surface characteristics of oxides as a result of the modifications neither alters the in vitro capability of Ca and P ion adsorption nor affects the metal ion dissolution behavior of the alloy. This implies that any influence on the cytocompatibility of the materials should only be correlated to the effect of surface chemistries of the alloy and the associated metal ion dissolution behavior of the alloy. The experimental results suggest that the cell response of neonatal rat calvarial osteoblasts on the Ti6Al4V alloy should neither be affected by the variation of surface chemistries of the alloy in a range studied.

AB - This study examined the cell attachment and proliferation of neonatal rat calvarial osteoblasts on Ti6Al4V alloy as affected by the surface modifications. The modifications could alter simultaneously the surface chemistries of the alloy (elemental difference of Ti, Al, V, Cu and Ni about 300-600μm thick examined by EDS) as well as the XPS nano-surface characteristics of oxides on the metal surface (chemistries of oxides, amphoteric OH group adsorbed on oxides, and oxide thickness). Three materials including two from modifications and a control were examined. It is argued that a slight change of the nano-surface characteristics of oxides as a result of the modifications neither alters the in vitro capability of Ca and P ion adsorption nor affects the metal ion dissolution behavior of the alloy. This implies that any influence on the cytocompatibility of the materials should only be correlated to the effect of surface chemistries of the alloy and the associated metal ion dissolution behavior of the alloy. The experimental results suggest that the cell response of neonatal rat calvarial osteoblasts on the Ti6Al4V alloy should neither be affected by the variation of surface chemistries of the alloy in a range studied.

UR - http://www.scopus.com/inward/record.url?scp=0142217397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142217397&partnerID=8YFLogxK

U2 - 10.1016/S0142-9612(03)00465-4

DO - 10.1016/S0142-9612(03)00465-4

M3 - Article

C2 - 14580905

AN - SCOPUS:0142217397

VL - 25

SP - 23

EP - 32

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 1

ER -