Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

Ya Shih Tseng, Ching Cherng Tzeng, Chi Ying F. Huang, Ping Hong Chen, Allen Wen Hsiang Chiu, Pei Yin Hsu, Guan Cheng Huang, Yu Chun Wang, Hsiao Sheng Liu

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12 Citations (Scopus)

Abstract

Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalCancer Letters
Volume241
Issue number1
DOIs
Publication statusPublished - 2006 Sep 8

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Tseng, Y. S., Tzeng, C. C., Huang, C. Y. F., Chen, P. H., Chiu, A. W. H., Hsu, P. Y., Huang, G. C., Wang, Y. C., & Liu, H. S. (2006). Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Letters, 241(1), 93-101. https://doi.org/10.1016/j.canlet.2005.10.014