Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold

Mohane Selvaraj Coumar, Jian Sung Wu, Jiun Shyang Leou, Uan Kang Tan, Chung Yu Chang, Teng Yuan Chang, Wen Hsing Lin, John T.A. Hsu, Yu Sheng Chao, Su Ying Wu, Hsing Pang Hsieh

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Tricyclic 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione was identified as a novel scaffold for Aurora kinase A inhibition through virtual screening. SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition.

Original languageEnglish
Pages (from-to)1623-1627
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number5
DOIs
Publication statusPublished - 2008 Mar 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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