TY - JOUR
T1 - Autoimmune connective tissue disease following carbon monoxide poisoning
T2 - A nationwide population-based cohort study
AU - Huang, Chien Cheng
AU - Ho, Chung Han
AU - Chen, Yi Chen
AU - Hsu, Chien Chin
AU - Lin, Hung Jung
AU - Wang, Jhi Joung
AU - Guo, How Ran
N1 - Funding Information:
This study was supported by grants MOST 109-2314-B-384-005-MY3 and MOST 108-2638-B-006-001-MY2 from the Ministry of Science and Technology and grants CMFHR10734 and CMFHR10832 from Chi Mei Medical Center. We thank Miss Ti Hsu for the English revision.
Funding Information:
This study was supported by grants MOST 109-2314-B-384-005-MY3 and MOST 108-2638-B-006-001-MY2 from the Ministry of Science and T echnology and grants CMFHR10734 and CMFHR10832 from Chi Mei Medical Center . W e thank Miss T i Hsu for the English revision.
Publisher Copyright:
© 2020 Huang et al.
PY - 2020
Y1 - 2020
N2 - Background: In addition to hypoxia, oxidative stress and inflammation due to carbon monoxide (CO) poisoning cause adverse health effects. These mechanisms are related to the occurrence of autoimmune connective tissue disease, but studies on the association between CO poisoning and autoimmune connective tissue disease are limited. We conducted a study to evaluate the occurrence of autoimmune connective tissue disease following CO poisoning. Methods: We identified participants with CO poisoning diagnosed between 1999 and 2012 from the Nationwide Poisoning Database and selected participants without CO poisoning from the Taiwan National Health Insurance Research Database with matching age and index dates at a 1:3 ratio. Sex, underlying comorbidities, and monthly income were also included in the analyses. We followed up the participants until 2013 and made comparison of the risk of autoimmune connective tissue disease between participants with and without CO poisoning. Results: The 23,877 participants with CO poisoning had a higher risk for autoimmune connective tissue disease than the 71,631 participants without CO poisoning (adjusted hazard ratio [AHR], 3.5; 95% confidence interval [CI], 3.1–3.9) after adjustment for sex, diabetes, Lyme disease, herpes zoster, infectious mononucleosis, hepatitis, HIV infection, liver dis-ease, renal disease, non-CO poisoning or drug abuse, malignancy, hypertension, hyperlipi-demia, coronary artery disease, congestive heart failure, chronic obstructive pulmonary disease, and monthly income. An increased risk was observed even after 4 years of follow-up (AHR, 3.6; 95% CI, 3.0–4.4). Conclusion: The risk of autoimmune connective tissue disease increased following CO poisoning. Close follow-up of the patients with CO poisoning for the development of connective tissue disease is recommended, and further investigation of the detailed mechanisms is warranted.
AB - Background: In addition to hypoxia, oxidative stress and inflammation due to carbon monoxide (CO) poisoning cause adverse health effects. These mechanisms are related to the occurrence of autoimmune connective tissue disease, but studies on the association between CO poisoning and autoimmune connective tissue disease are limited. We conducted a study to evaluate the occurrence of autoimmune connective tissue disease following CO poisoning. Methods: We identified participants with CO poisoning diagnosed between 1999 and 2012 from the Nationwide Poisoning Database and selected participants without CO poisoning from the Taiwan National Health Insurance Research Database with matching age and index dates at a 1:3 ratio. Sex, underlying comorbidities, and monthly income were also included in the analyses. We followed up the participants until 2013 and made comparison of the risk of autoimmune connective tissue disease between participants with and without CO poisoning. Results: The 23,877 participants with CO poisoning had a higher risk for autoimmune connective tissue disease than the 71,631 participants without CO poisoning (adjusted hazard ratio [AHR], 3.5; 95% confidence interval [CI], 3.1–3.9) after adjustment for sex, diabetes, Lyme disease, herpes zoster, infectious mononucleosis, hepatitis, HIV infection, liver dis-ease, renal disease, non-CO poisoning or drug abuse, malignancy, hypertension, hyperlipi-demia, coronary artery disease, congestive heart failure, chronic obstructive pulmonary disease, and monthly income. An increased risk was observed even after 4 years of follow-up (AHR, 3.6; 95% CI, 3.0–4.4). Conclusion: The risk of autoimmune connective tissue disease increased following CO poisoning. Close follow-up of the patients with CO poisoning for the development of connective tissue disease is recommended, and further investigation of the detailed mechanisms is warranted.
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U2 - 10.2147/CLEP.S266396
DO - 10.2147/CLEP.S266396
M3 - Article
AN - SCOPUS:85096379486
SN - 1179-1349
VL - 12
SP - 1287
EP - 1298
JO - Clinical Epidemiology
JF - Clinical Epidemiology
ER -