Autophagy facilitates an IFN-γ response and signal transduction

Yu Ping Chang, Chia Ling Chen, Su O. Chen, Yee Shin Lin, Cheng Chieh Tsai, Wei Ching Huang, Chi Yun Wang, Chia Yuan Hsieh, Pui Ching Choi, Chiou Feng Lin

Research output: Contribution to journalShort survey

11 Citations (Scopus)

Abstract

Autophagy, that is directly triggered by invaded pathogens and indirectly triggered by IFN-γ, acts as a defense by mediating intracellular microbial recognition and clearance. In addition, autophagy contributes to inflammation by facilitating an IFN-γ response and signal transduction. For immune escape, downregulated autophagy may be a strategy used by microbes.

Original languageEnglish
Pages (from-to)888-894
Number of pages7
JournalMicrobes and Infection
Volume13
Issue number11
DOIs
Publication statusPublished - 2011 Oct 1

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All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Chang, Y. P., Chen, C. L., Chen, S. O., Lin, Y. S., Tsai, C. C., Huang, W. C., Wang, C. Y., Hsieh, C. Y., Choi, P. C., & Lin, C. F. (2011). Autophagy facilitates an IFN-γ response and signal transduction. Microbes and Infection, 13(11), 888-894. https://doi.org/10.1016/j.micinf.2011.05.008