Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases

Rong-Jane Chen, Yu-Hsuan Lee, Ya Ling Yeh, Wun Syuan Wu, Chi Tang Ho, Chia Yi Li, Bour Jr Wang, Ying-Jan Wang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pterostilbene is a naturally occurring analog of resveratrol with many health benefits. These health benefits are associated with its antioxidant activity, anti-inflammatory effects, and chemopreventive effects attributed to its unique structure. The skin cancer chemopreventive potential of pterostilbene is supported by a variety of mechanistic studies confirming the anti-inflammatory effects in skin cancer models. Molecular biological studies have identified that pterostilbene targets pleotropic signaling pathways, including those involved in mitogenesis, cell cycle regulation, and apoptosis. Recently, pterostilbene has been reported to induce autophagy in cancer and normal cells. Through autophagy induction, the inflammatory-related skin diseases can be attenuated. This finding suggests the potential use of pterostilbene in the treatment and prevention of skin disorders via alleviating inflammatory responses by autophagy induction. This review summarizes the protective and therapeutic benefits of pterostilbene in skin diseases from the viewpoint of its antioxidant, anti-inflammatory, and autophagy-inducing effects. Novel underlying mechanisms regarding these effects are discussed. We proposed that pterostilbene, a promising natural product, can be used as a preventive and therapeutic agent for inflammation-related skin disorders through induction of autophagy.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalJournal of Food and Drug Analysis
Volume25
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

autophagy
Autophagy
skin diseases
Skin Diseases
therapeutics
Anti-Inflammatory Agents
Skin Neoplasms
Insurance Benefits
anti-inflammatory activity
Therapeutics
Antioxidants
inflammation
Skin
resveratrol
pterostilbene
Biological Products
cell cycle
Cell Cycle
apoptosis
antioxidant activity

All Science Journal Classification (ASJC) codes

  • Food Science
  • Pharmacology

Cite this

Chen, Rong-Jane ; Lee, Yu-Hsuan ; Yeh, Ya Ling ; Wu, Wun Syuan ; Ho, Chi Tang ; Li, Chia Yi ; Wang, Bour Jr ; Wang, Ying-Jan. / Autophagy-inducing effect of pterostilbene : A prospective therapeutic/preventive option for skin diseases. In: Journal of Food and Drug Analysis. 2017 ; Vol. 25, No. 1. pp. 125-133.
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Autophagy-inducing effect of pterostilbene : A prospective therapeutic/preventive option for skin diseases. / Chen, Rong-Jane; Lee, Yu-Hsuan; Yeh, Ya Ling; Wu, Wun Syuan; Ho, Chi Tang; Li, Chia Yi; Wang, Bour Jr; Wang, Ying-Jan.

In: Journal of Food and Drug Analysis, Vol. 25, No. 1, 01.01.2017, p. 125-133.

Research output: Contribution to journalArticle

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