Abstract
Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.
| Original language | English |
|---|---|
| Pages (from-to) | 665-670 |
| Number of pages | 6 |
| Journal | Journal of Attention Disorders |
| Volume | 23 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2019 May 1 |
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All Science Journal Classification (ASJC) codes
- Developmental and Educational Psychology
- Clinical Psychology
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Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD. / Tai, Ying-Chun; Chi, Mei-Hung; Chu, Ching Lin; Chiu, Nan-Tsing; Yao, Wei-Jen; Chen, Po-See; Yang, Yen-Kuang.
In: Journal of Attention Disorders, Vol. 23, No. 7, 01.05.2019, p. 665-670.Research output: Contribution to journal › Article
TY - JOUR
T1 - Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD
AU - Tai, Ying-Chun
AU - Chi, Mei-Hung
AU - Chu, Ching Lin
AU - Chiu, Nan-Tsing
AU - Yao, Wei-Jen
AU - Chen, Po-See
AU - Yang, Yen-Kuang
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.
AB - Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.
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U2 - 10.1177/1087054716654570
DO - 10.1177/1087054716654570
M3 - Article
VL - 23
SP - 665
EP - 670
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
SN - 1087-0547
IS - 7
ER -