Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD

Ying Chun Tai; Mei Hung Chi; Ching Lin Chu; Nan Tsing Chiu; Wei Jen Yao; Po See Chen; Yen Kuang Yang

doi:10.1177/1087054716654570

Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD

Ying Chun Tai, Mei Hung Chi, Ching Lin Chu, Nan Tsing Chiu, Wei Jen Yao, Po See Chen, Yen Kuang Yang

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ ^99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.

Original language	English
Pages (from-to)	665-670
Number of pages	6
Journal	Journal of Attention Disorders
Volume	23
Issue number	7
DOIs	https://doi.org/10.1177/1087054716654570
Publication status	Published - 2019 May 1

All Science Journal Classification (ASJC) codes

Developmental and Educational Psychology
Clinical Psychology

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@article{3ad1fde6a5464bf594cd716c736a5fb6,

title = "Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD",

abstract = " Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities. ",

author = "Tai, {Ying Chun} and Chi, {Mei Hung} and Chu, {Ching Lin} and Chiu, {Nan Tsing} and Yao, {Wei Jen} and Chen, {Po See} and Yang, {Yen Kuang}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Science Council of Taiwan (NSC 100-2314-B-006-041-MY3, NSC 101-2314-B-006-065, and NSC 102-2420-H-006-007-MY2), the Ministry of Science and Technology, Republic of China (MOST 104-2314-B-006-053-MY2), and National Cheng Kung University Hospital (NCKUH-10104019 and NCKUH-10405033). This research also received funding (D102-35001 and D103-35A09) from the Headquarters of University Advancement at the National Cheng Kung University, which is sponsored by the Ministry of Education, Taiwan, Republic of China.",

year = "2019",

month = may,

day = "1",

doi = "10.1177/1087054716654570",

language = "English",

volume = "23",

pages = "665--670",

journal = "Journal of Attention Disorders",

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T1 - Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD

AU - Tai, Ying Chun

AU - Chi, Mei Hung

AU - Chu, Ching Lin

AU - Chiu, Nan Tsing

AU - Yao, Wei Jen

AU - Chen, Po See

AU - Yang, Yen Kuang

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Science Council of Taiwan (NSC 100-2314-B-006-041-MY3, NSC 101-2314-B-006-065, and NSC 102-2420-H-006-007-MY2), the Ministry of Science and Technology, Republic of China (MOST 104-2314-B-006-053-MY2), and National Cheng Kung University Hospital (NCKUH-10104019 and NCKUH-10405033). This research also received funding (D102-35001 and D103-35A09) from the Headquarters of University Advancement at the National Cheng Kung University, which is sponsored by the Ministry of Education, Taiwan, Republic of China.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.

AB - Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.

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