@article{3ad1fde6a5464bf594cd716c736a5fb6,
title = "Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD",
abstract = " Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities. ",
author = "Tai, {Ying Chun} and Chi, {Mei Hung} and Chu, {Ching Lin} and Chiu, {Nan Tsing} and Yao, {Wei Jen} and Chen, {Po See} and Yang, {Yen Kuang}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Science Council of Taiwan (NSC 100-2314-B-006-041-MY3, NSC 101-2314-B-006-065, and NSC 102-2420-H-006-007-MY2), the Ministry of Science and Technology, Republic of China (MOST 104-2314-B-006-053-MY2), and National Cheng Kung University Hospital (NCKUH-10104019 and NCKUH-10405033). This research also received funding (D102-35001 and D103-35A09) from the Headquarters of University Advancement at the National Cheng Kung University, which is sponsored by the Ministry of Education, Taiwan, Republic of China. Funding Information: The authors also wish to thank Professor Yuan-Hwa Chou from Taipei Veterans General Hospital, Ms. Tsai Hua Chang, Mr. Chien Ting Lin, and all of the research participants. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Science Council of Taiwan (NSC 100-2314-B-006-041-MY3, NSC 101-2314-B-006-065, and NSC 102-2420-H-006-007-MY2), the Ministry of Science and Technology, Republic of China (MOST 104-2314-B-006-053-MY2), and National Cheng Kung University Hospital (NCKUH-10104019 and NCKUH-10405033). This research also received funding (D102-35001 and D103-35A09) from the Headquarters of University Advancement at the National Cheng Kung University, which is sponsored by the Ministry of Education, Taiwan, Republic of China. Publisher Copyright: {\textcopyright} The Author(s) 2016.",
year = "2019",
month = may,
day = "1",
doi = "10.1177/1087054716654570",
language = "English",
volume = "23",
pages = "665--670",
journal = "Journal of Attention Disorders",
issn = "1087-0547",
publisher = "SAGE Publications Inc.",
number = "7",
}