Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity

Tun Hui Wu; Zih Syuan Su; Robert Sung; Kuangsen Sung

doi:10.1002/cphc.201901133

Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity

Tun Hui Wu, Zih Syuan Su, Robert Sung, Kuangsen Sung

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined.

Original language	English
Pages (from-to)	307-312
Number of pages	6
Journal	ChemPhysChem
Volume	21
Issue number	4
DOIs	https://doi.org/10.1002/cphc.201901133
Publication status	Published - 2020 Feb 17

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry

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10.1002/cphc.201901133

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AU - Sung, Kuangsen

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Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity

Abstract

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