Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity

Tun Hui Wu, Zih Syuan Su, Robert Sung, Kuangsen Sung

Research output: Contribution to journalArticle

Abstract

Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined.

Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalChemPhysChem
Volume21
Issue number4
DOIs
Publication statusPublished - 2020 Feb 17

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All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

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