Abstract
Background: Patients with diabetes mellitus have an increased risk of infection. The roles of bacterial characteristics and glycemic control in diabetic patients with Escherichia coli infection have not been well investigated. The aims of this study were to examine the bacterial characteristics and glycemic control in diabetic patients with E. coli infections arising in the urinary tract. Methods: A total of 271 E. coli isolates were collected from urine and bloodstream. Phylogenetic groups, the presence of virulence genes, and antimicrobial susceptibility of E. coli isolates were determined. Results: There were few differences in E. coli bacterial characteristics between 190 diabetic and 81 nondiabetic patients. In diabetic patients with urosepsis, there was a higher hemoglobin A1C level, and the related E. coli strains had more neuA, papG II, afa and hlyA genes, and a lower prevalence of antimicrobial resistance to cephalosporins and fluoroquinolones than those with asymptomatic bacteriuria and urinary tract infection. Multivariate logistic regression analysis revealed that increased hemoglobin A1C and presence of papG II and afa genes were independent factors associated with development of urosepsis in diabetic patients. Conclusion: This study demonstrated that more virulent E. coli isolates, especially with papG II and afa genes, and poorer glycemic control were important determinants for development of urosepsis in diabetic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 24-29 |
| Number of pages | 6 |
| Journal | Journal of Microbiology, Immunology and Infection |
| Volume | 46 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology and Microbiology(all)
- Microbiology (medical)
- Infectious Diseases
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Bacterial characteristics and glycemic control in diabetic patients with Escherichia coli urinary tract infection. / Wang, Ming-Cheng; Tseng, Chin-Chung; Wu, An-Bang; Lin, Wei-Hung; Teng, Ching-Hao; Yan, Jing Jou; Wu, Jiunn Jong.
In: Journal of Microbiology, Immunology and Infection, Vol. 46, No. 1, 01.02.2013, p. 24-29.Research output: Contribution to journal › Article
TY - JOUR
T1 - Bacterial characteristics and glycemic control in diabetic patients with Escherichia coli urinary tract infection
AU - Wang, Ming-Cheng
AU - Tseng, Chin-Chung
AU - Wu, An-Bang
AU - Lin, Wei-Hung
AU - Teng, Ching-Hao
AU - Yan, Jing Jou
AU - Wu, Jiunn Jong
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Background: Patients with diabetes mellitus have an increased risk of infection. The roles of bacterial characteristics and glycemic control in diabetic patients with Escherichia coli infection have not been well investigated. The aims of this study were to examine the bacterial characteristics and glycemic control in diabetic patients with E. coli infections arising in the urinary tract. Methods: A total of 271 E. coli isolates were collected from urine and bloodstream. Phylogenetic groups, the presence of virulence genes, and antimicrobial susceptibility of E. coli isolates were determined. Results: There were few differences in E. coli bacterial characteristics between 190 diabetic and 81 nondiabetic patients. In diabetic patients with urosepsis, there was a higher hemoglobin A1C level, and the related E. coli strains had more neuA, papG II, afa and hlyA genes, and a lower prevalence of antimicrobial resistance to cephalosporins and fluoroquinolones than those with asymptomatic bacteriuria and urinary tract infection. Multivariate logistic regression analysis revealed that increased hemoglobin A1C and presence of papG II and afa genes were independent factors associated with development of urosepsis in diabetic patients. Conclusion: This study demonstrated that more virulent E. coli isolates, especially with papG II and afa genes, and poorer glycemic control were important determinants for development of urosepsis in diabetic patients.
AB - Background: Patients with diabetes mellitus have an increased risk of infection. The roles of bacterial characteristics and glycemic control in diabetic patients with Escherichia coli infection have not been well investigated. The aims of this study were to examine the bacterial characteristics and glycemic control in diabetic patients with E. coli infections arising in the urinary tract. Methods: A total of 271 E. coli isolates were collected from urine and bloodstream. Phylogenetic groups, the presence of virulence genes, and antimicrobial susceptibility of E. coli isolates were determined. Results: There were few differences in E. coli bacterial characteristics between 190 diabetic and 81 nondiabetic patients. In diabetic patients with urosepsis, there was a higher hemoglobin A1C level, and the related E. coli strains had more neuA, papG II, afa and hlyA genes, and a lower prevalence of antimicrobial resistance to cephalosporins and fluoroquinolones than those with asymptomatic bacteriuria and urinary tract infection. Multivariate logistic regression analysis revealed that increased hemoglobin A1C and presence of papG II and afa genes were independent factors associated with development of urosepsis in diabetic patients. Conclusion: This study demonstrated that more virulent E. coli isolates, especially with papG II and afa genes, and poorer glycemic control were important determinants for development of urosepsis in diabetic patients.
UR - http://www.scopus.com/inward/record.url?scp=84872611363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872611363&partnerID=8YFLogxK
U2 - 10.1016/j.jmii.2011.12.024
DO - 10.1016/j.jmii.2011.12.024
M3 - Article
C2 - 22572000
AN - SCOPUS:84872611363
VL - 46
SP - 24
EP - 29
JO - Journal of Microbiology, Immunology and Infection
JF - Journal of Microbiology, Immunology and Infection
SN - 1684-1182
IS - 1
ER -