Baicalein protects against oxLDL-caused oxidative stress and inflammation by modulation of AMPK- alpha

Kun Ling Tsai, Ching Hsia Hung, Shih Hung Chan, Jhih Yuan Shih, Yung Hsin Cheng, Yi Ju Tsai, Huei Chen Lin, Pei Ming Chu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Atherosclerosis is considered to be a form of chronic inflammation and a disorder of lipid metabolism. Oxidative transformations in the lipid and apolipoprotein B (Apo B) constituent of low density lipoprotein drive the initial step in atherogenesis due to macrophage scavenger receptors identify oxidized LDL (oxLDL) but non-oxidized LDL. The human vascular endothelial cells fact a critical role in vasodilation, provides a nonadhesive surface for circulation, reduces vascular smooth muscle proliferation, inflammation, thrombus formation and platelet aggregation. Assembly of oxLDL contribute to stimulation of endothelial cells with up-regulation of adhesion molecules, increase oxidative stress to the vascular endothelium and inhibition of NO-mediated vasodilation. When adhesion molecules are over-expressed on the surface of endothelial cells under oxLDL stimulation, it will recruit monocytes to the arterial wall. Then adherent monocytes will migrate into the subendothelial space and subsequently differentiate into macrophages. In the subendothelial space, oxLDL will be taken up by macrophages, thereby causing the substantial cholesterol accumulation and the foam cells production.

Original languageEnglish
Pages (from-to)72458-72468
Number of pages11
JournalOncotarget
Volume7
Issue number45
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Oncology

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