Betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC): A prospective biomarker prevalence study

Ruey Long Hong; Chia Jui Yen; Ming Yu Lien; Rebecca Cheng; Yu Wen Su; Han Nan Lin; Song Ling Poon; Chih Yen Chien

doi:10.1016/j.oraloncology.2024.106760

Betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC): A prospective biomarker prevalence study

Ruey Long Hong, Chia Jui Yen, Ming Yu Lien, Rebecca Cheng, Yu Wen Su, Han Nan Lin, Song Ling Poon, Chih Yen Chien

Department of Oncology

Research output: Contribution to journal › Letter › peer-review

2 Citations (Scopus)

Abstract

This study explored the relationship between betel-nut chewing and programmed death-ligand 1 (PD-L1) expression in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients in Taiwan. A total 280 R/M HNSCC patients, predominantly male, were evaluated; 75.4 % of whom chewed betel-nut. The prevalence of PD-L1 expression (combined positive score ≥1) was 94.3 % with similar PD-L1 expression rates between betel-nut-exposed and non-exposed groups. PD-L1 prevalence did not differ in those who received prior first-or second-line systemic therapy. In summary, betel-nut exposure did not notably affect PD-L1 expression rates in R/M HNSCC patients in Taiwan.

Original language	English
Article number	106760
Journal	Oral Oncology
Volume	152
DOIs	https://doi.org/10.1016/j.oraloncology.2024.106760
Publication status	Published - 2024 May

All Science Journal Classification (ASJC) codes

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2024.106760

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@article{4ce533b5ccfd43c6a275830813cdf1f4,

title = "Betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC): A prospective biomarker prevalence study",

abstract = "This study explored the relationship between betel-nut chewing and programmed death-ligand 1 (PD-L1) expression in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients in Taiwan. A total 280 R/M HNSCC patients, predominantly male, were evaluated; 75.4 % of whom chewed betel-nut. The prevalence of PD-L1 expression (combined positive score ≥1) was 94.3 % with similar PD-L1 expression rates between betel-nut-exposed and non-exposed groups. PD-L1 prevalence did not differ in those who received prior first-or second-line systemic therapy. In summary, betel-nut exposure did not notably affect PD-L1 expression rates in R/M HNSCC patients in Taiwan.",

author = "Hong, {Ruey Long} and Yen, {Chia Jui} and Lien, {Ming Yu} and Rebecca Cheng and Su, {Yu Wen} and Lin, {Han Nan} and Poon, {Song Ling} and Chien, {Chih Yen}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = may,

doi = "10.1016/j.oraloncology.2024.106760",

language = "English",

volume = "152",

journal = "Oral Oncology",

issn = "1368-8375",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC)

T2 - A prospective biomarker prevalence study

AU - Hong, Ruey Long

AU - Yen, Chia Jui

AU - Lien, Ming Yu

AU - Cheng, Rebecca

AU - Su, Yu Wen

AU - Lin, Han Nan

AU - Poon, Song Ling

AU - Chien, Chih Yen

PY - 2024/5

Y1 - 2024/5

N2 - This study explored the relationship between betel-nut chewing and programmed death-ligand 1 (PD-L1) expression in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients in Taiwan. A total 280 R/M HNSCC patients, predominantly male, were evaluated; 75.4 % of whom chewed betel-nut. The prevalence of PD-L1 expression (combined positive score ≥1) was 94.3 % with similar PD-L1 expression rates between betel-nut-exposed and non-exposed groups. PD-L1 prevalence did not differ in those who received prior first-or second-line systemic therapy. In summary, betel-nut exposure did not notably affect PD-L1 expression rates in R/M HNSCC patients in Taiwan.

AB - This study explored the relationship between betel-nut chewing and programmed death-ligand 1 (PD-L1) expression in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients in Taiwan. A total 280 R/M HNSCC patients, predominantly male, were evaluated; 75.4 % of whom chewed betel-nut. The prevalence of PD-L1 expression (combined positive score ≥1) was 94.3 % with similar PD-L1 expression rates between betel-nut-exposed and non-exposed groups. PD-L1 prevalence did not differ in those who received prior first-or second-line systemic therapy. In summary, betel-nut exposure did not notably affect PD-L1 expression rates in R/M HNSCC patients in Taiwan.

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UR - http://www.scopus.com/inward/citedby.url?scp=85188713833&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2024.106760

DO - 10.1016/j.oraloncology.2024.106760

M3 - Letter

C2 - 38520758

AN - SCOPUS:85188713833

SN - 1368-8375

VL - 152

JO - Oral Oncology

JF - Oral Oncology

M1 - 106760

ER -

Betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC): A prospective biomarker prevalence study

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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