Bidirectional associations between rheumatoid arthritis and depression

A nationwide longitudinal study

Ming Chi Lu, How-Ran Guo, Miao Chiu Lin, Hanoch Livneh, Ning Sheng Lai, Tzung Yi Tsai

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) and depression may be associated with each other pathophysiologically, but few studies have been conducted on the interplay between these two diseases using longitudinal measurement. Therefore, we used the National Health Insurance Research Database of Taiwan to investigate the bidirectional associations between RA and depression. One cohort was included to analyze RA predicting the onset of depression and a second cohort for analysis of depression predicting RA. A sex- and age-matched control group was included for both. The incidence of depression in RA subjects was higher than in non-RA subjects [15.69 vs. 8.95 per 1,000 person-years (PYs)], with an adjusted hazard ratios (HRs) of 1.69 [95% confidence interval (CI), 1.51-1.87]. The incidence of RA was higher in depressed than non-depressed individuals (2.07 vs. 1.21 per 1,000 PYs), with an adjusted HRs of 1.65 (95% CI, 1.41-1.77). This population-based cohort study suggested strong bidirectional relationships between RA and depression. Healthcare providers are recommended to facilitate the implementation of more effective therapeutic interventions to achieve favorable prognosis, especially for those with new-onset or younger cases.

Original languageEnglish
Article number20647
JournalScientific reports
Volume6
DOIs
Publication statusPublished - 2016 Feb 9

Fingerprint

Longitudinal Studies
Rheumatoid Arthritis
Cohort Studies
Confidence Intervals
Incidence
National Health Programs
Taiwan
Health Personnel
Arthritis
Research Design
Databases
Control Groups
Research
Population

All Science Journal Classification (ASJC) codes

  • General

Cite this

Lu, Ming Chi ; Guo, How-Ran ; Lin, Miao Chiu ; Livneh, Hanoch ; Lai, Ning Sheng ; Tsai, Tzung Yi. / Bidirectional associations between rheumatoid arthritis and depression : A nationwide longitudinal study. In: Scientific reports. 2016 ; Vol. 6.
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Bidirectional associations between rheumatoid arthritis and depression : A nationwide longitudinal study. / Lu, Ming Chi; Guo, How-Ran; Lin, Miao Chiu; Livneh, Hanoch; Lai, Ning Sheng; Tsai, Tzung Yi.

In: Scientific reports, Vol. 6, 20647, 09.02.2016.

Research output: Contribution to journalArticle

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