Bidirectional relationship between primary sjögren syndrome and non-hodgkin lymphoma: A nationwide taiwanese population-based study

Li Hui Wang, Wei Ming Wang, Chun Yu Lin, Sheng Hsiang Lin, Chi Chang Shieh

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. Bidirectional relationships between some autoimmune diseases and non-Hodgkin lymphoma (NHL) may exist. We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between primary Sjögren syndrome (pSS) and NHL. Methods. Using the National Health Insurance Research Database of Taiwan, we identified 15,636 patients with new-onset pSS without previous cancer and 25,074 patients with new-onset NHL without previous pSS as 2 non-overlapping cohorts from 1998 to 2012, and followed them until 2013. Standardized incidence ratios (SIR) for NHL in the patients with pSS and SIR for pSS in the patients with NHL were compared with the general population. Results. Among the 15,636 patients with pSS, 741 developed cancers, including 51 with NHL. The highest SIR of specific cancer risk in patients with pSS was that for NHL (SIR 4.6, 95% CI 3.4–6.0). Among the 25,074 patients with NHL, 49 developed pSS; the SIR was also increased (SIR 3.2, 95% CI 2.4–4.2). The risk was highest within 1 year after the diagnosis of each disease. Conclusion. This nationwide population-based study is the first to report a bidirectional relationship between pSS and NHL. Our findings suggest being alert for patients with pSS or NHL who have early signs of the other disease in clinical care. The underlying mechanisms of the bidirectional relationship merit further investigation.

Original languageEnglish
Pages (from-to)1374-1378
Number of pages5
JournalJournal of Rheumatology
Volume47
Issue number9
DOIs
Publication statusPublished - 2020 Sep 1

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Bidirectional relationship between primary sjögren syndrome and non-hodgkin lymphoma: A nationwide taiwanese population-based study'. Together they form a unique fingerprint.

Cite this