Abstract
This paper reports dual function Gd2O3/C nanoshells for application in MR contrast images and NIR-triggered killing cancer cells. The nanoshells are prepared using biological gelatin particles as core templates through a two-step thermal treatment The surfaces of the nanoshells can be readily modified by poly(styrene-alt-maleic acid) (PSMA) polymer to improve their water-dispersible properties and increase their biocompatibility. The Gd2O3/C nanoshells show brightened images of kidney cortex and liver in mice, whereas the Gd2O3/C @ PSMA nanoshells show a darkened liver signal. The biodistribution is measured as a function of time and shows that the nanoshells circulate in the vessels and are cleared out gradually from organs. The graphite carbon coated on the Gd2O 3 nanoshells displays absorbance in the near-IR (NIR) region. A large extinction coefficient is obtained, indicating the potential of the nanoshells as photothermal agents. The Gd2O3/C @ PSMA nanoshells conjugated with anti-epithermal growth factor receptor antibodies are used for targeting and destroying A549 lung cancer cells by means of NIR-triggered killing capability. Both laser power density and material dose dependence are investigated to evaluate photothermolysis in cancer cells.
Original language | English |
---|---|
Pages (from-to) | 249-258 |
Number of pages | 10 |
Journal | Advanced Functional Materials |
Volume | 19 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2009 Jan 23 |
All Science Journal Classification (ASJC) codes
- Condensed Matter Physics
- General Chemistry
- General Materials Science