Bifunctional Cd2O3/C nanoshells for MR imaging and NIR therapeutic applications

Chih Chia Huang, Chia Hao Su, Wei Ming Li, Tzu Yu Liu, Jyh Horng Chen, Chen Sheng Yeh

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

This paper reports dual function Gd2O3/C nanoshells for application in MR contrast images and NIR-triggered killing cancer cells. The nanoshells are prepared using biological gelatin particles as core templates through a two-step thermal treatment The surfaces of the nanoshells can be readily modified by poly(styrene-alt-maleic acid) (PSMA) polymer to improve their water-dispersible properties and increase their biocompatibility. The Gd2O3/C nanoshells show brightened images of kidney cortex and liver in mice, whereas the Gd2O3/C @ PSMA nanoshells show a darkened liver signal. The biodistribution is measured as a function of time and shows that the nanoshells circulate in the vessels and are cleared out gradually from organs. The graphite carbon coated on the Gd2O 3 nanoshells displays absorbance in the near-IR (NIR) region. A large extinction coefficient is obtained, indicating the potential of the nanoshells as photothermal agents. The Gd2O3/C @ PSMA nanoshells conjugated with anti-epithermal growth factor receptor antibodies are used for targeting and destroying A549 lung cancer cells by means of NIR-triggered killing capability. Both laser power density and material dose dependence are investigated to evaluate photothermolysis in cancer cells.

Original languageEnglish
Pages (from-to)249-258
Number of pages10
JournalAdvanced Functional Materials
Volume19
Issue number2
DOIs
Publication statusPublished - 2009 Jan 23

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • General Chemistry
  • General Materials Science

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