Bioactive alkaloids from Illigera luzonensis

Keh Shaw Chen; Yang Chang Wu; Che Ming Teng; Feng Nien Ko; Tian Shung Wu

doi:10.1021/np9700735

Bioactive alkaloids from Illigera luzonensis

Keh Shaw Chen, Yang Chang Wu, Che Ming Teng, Feng Nien Ko, Tian Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Using antiplatelet aggregation as a guide to fractionation, seven aporphines, actinodaphnine (1), N-methylactinodaphnine (2), launobine (3), dicentrine (4), O-methylbulbocapnine (5), hernovine (7), and bulbocapnine (9), and two oxoaporphines, dicentrinone (6) and liriodenine (8), were isolated from the stems of Illigera luzonensis. Among them, compounds 2, 4, 5, 8, and 9 were isolated for the first time from this species. Moreover, compounds 1-5, 7, and 8 showed significant antiplatelet aggregation and compounds 1 and 6 exhibited significant vasorelaxant activities, respectively.

Original language	English
Pages (from-to)	645-647
Number of pages	3
Journal	Journal of Natural Products
Volume	60
Issue number	6
DOIs	https://doi.org/10.1021/np9700735
Publication status	Published - 1997 Jun

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np9700735

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title = "Bioactive alkaloids from Illigera luzonensis",

abstract = "Using antiplatelet aggregation as a guide to fractionation, seven aporphines, actinodaphnine (1), N-methylactinodaphnine (2), launobine (3), dicentrine (4), O-methylbulbocapnine (5), hernovine (7), and bulbocapnine (9), and two oxoaporphines, dicentrinone (6) and liriodenine (8), were isolated from the stems of Illigera luzonensis. Among them, compounds 2, 4, 5, 8, and 9 were isolated for the first time from this species. Moreover, compounds 1-5, 7, and 8 showed significant antiplatelet aggregation and compounds 1 and 6 exhibited significant vasorelaxant activities, respectively.",

author = "Chen, {Keh Shaw} and Wu, {Yang Chang} and Teng, {Che Ming} and Ko, {Feng Nien} and Wu, {Tian Shung}",

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T1 - Bioactive alkaloids from Illigera luzonensis

AU - Chen, Keh Shaw

AU - Wu, Yang Chang

AU - Teng, Che Ming

AU - Ko, Feng Nien

AU - Wu, Tian Shung

PY - 1997/6

Y1 - 1997/6

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AB - Using antiplatelet aggregation as a guide to fractionation, seven aporphines, actinodaphnine (1), N-methylactinodaphnine (2), launobine (3), dicentrine (4), O-methylbulbocapnine (5), hernovine (7), and bulbocapnine (9), and two oxoaporphines, dicentrinone (6) and liriodenine (8), were isolated from the stems of Illigera luzonensis. Among them, compounds 2, 4, 5, 8, and 9 were isolated for the first time from this species. Moreover, compounds 1-5, 7, and 8 showed significant antiplatelet aggregation and compounds 1 and 6 exhibited significant vasorelaxant activities, respectively.

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Bioactive alkaloids from Illigera luzonensis

Abstract

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