Bioactive chemical constituents from the root bark of Morus australis

Yu Ren Liao, Ping Chung Kuo, Wei Jern Tsai, Guan Jhong Huang, Kuo Hsiung Lee, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Two new pyranoflavonoids, morustralins A (1) and B (2), a new natural benzene derivative, one benzenoid (Z)-1-hydroxy-4-(2-nitroethenyl)benzene (3), and thirty known compounds were isolated and characterized from the root bark of Morus australis. The structures of the new compounds were established from spectroscopic and spectrometric analyses. Ten isolates (1–10) were examined for inhibitory effects on adenosine diphosphate (ADP)-, arachidonic acid (AA)-, and platelet-aggregating factor (PAF)-induced platelet aggregation. Among the tested compounds, compound 3 displayed the most significant inhibition of ADP- and AA-induced platelet aggregation with IC50values of 9.76 ± 5.54 and 9.81 ± 2.7 μM, respectively. In addition, eight purified compounds (3–10) were examined for inhibition of nitric oxide (NO) production in RAW 264.7 cells and six compounds (3–8) displayed significant inhibitory effects with IC50values ranging from 2.1 ± 0.3 to 6.3 ± 0.6 μM.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number2
DOIs
Publication statusPublished - 2017 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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