Bioactive naphthoquinones and triterpenoids from the fruiting bodies of Taiwanofungus salmoneus

Kun Ching Cheng, Chin Fu Chen, Chin Chuan Hung, Sio Hong Lam, Hsin Yi Hung, Yue Chiun Li, Fu An Chen, Po Chuen Shieh, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Drug resistance of cancer cells stands for the major problem of the treatment failure for chemotherapy or target therapy. Overexpression of efflux pumps leading to multidrug resistance (MDR) is still an important issue needed to be solved. In the present study, Taiwanofungus salmoneus was selected as the topic and eleven undescribed constituents including four naphthoquinones salmonones A-D (1–4) and seven triterpenoids salmoneatins A-G (5–11), along with one chromanone (12) and two benzenoids (13 and 14) reported from the natural sources for the first time, as well as twenty-one known compounds were characterized. The structures of undescribed compounds were established by the spectroscopic and spectrometric analyses. In addition, the plausible biosynthetic mechanism of purified naphthoquinones was proposed and these compounds may be the excellent chemotaxonomic markers. Moreover, the isolates were evaluated for their P-gp inhibitory effects and the results showed that most of the examined compounds were effective. Among the tested compounds, 5, 10, 2,3-dimethoxy-5-(2ʹ,5ʹ-dimethoxy-3ʹ,4ʹ-methylenedioxyphenyl)-7-methyl-[1,4]naphthoquinone, zhankuic acid A methyl ester, and camphoratin F can reverse the resistance of paclitaxel or vincristine with the reversal folds in the range of 51093.3 and 259.5. These experimental data would initiate the possible development of Taiwanofungus salmoneus for the cancer therapy in the future.

Original languageEnglish
Article number104939
JournalBioorganic Chemistry
Volume112
DOIs
Publication statusPublished - 2021 Jul

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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