Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

Shih Huang Tai, Ping Chung Kuo, Ching Che Hung, Ying Hsuan Lin, Tsong Long Hwang, Sio Hong Lam, Daih Huang Kuo, Jin Bin Wu, Hsin Yi Hung, Tian-Shung Wu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

Original languageEnglish
Pages (from-to)34184-34195
Number of pages12
JournalRSC Advances
Volume9
Issue number59
DOIs
Publication statusPublished - 2019 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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