Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

Shih Huang Tai, Ping Chung Kuo, Ching Che Hung, Ying Hsuan Lin, Tsong Long Hwang, Sio Hong Lam, Daih Huang Kuo, Jin Bin Wu, Hsin Yi Hung, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

Original languageEnglish
Pages (from-to)34184-34195
Number of pages12
JournalRSC Advances
Volume9
Issue number59
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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