Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy

Yu Jen Lu; Chih Wen Lin; Hung Wei Yang; Kun Ju Lin; Shiaw Pyng Wey; Chia Liang Sun; Kuo Chen Wei; Tzu Chen Yen; Ching I. Lin; Chen Chi M. Ma; Jyh Ping Chen

doi:10.1016/j.carbon.2014.03.007

Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy

Yu Jen Lu, Chih Wen Lin, Hung Wei Yang, Kun Ju Lin, Shiaw Pyng Wey, Chia Liang Sun, Kuo Chen Wei, Tzu Chen Yen, Ching I. Lin, Chen Chi M. Ma, Jyh Ping Chen

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

To use graphene oxide nanoribbons (GONRs) in combination with chemo-photothermal therapy, we modified GONRs with phospholipid-polyethylene glycol (PL-PEG) to prepare PEGylated GONRs (PL-PEG-GONRs), followed by investigation of the short-term in vivo biodistribution of ^99mTc- labeled PL-PEG-GONRs and their excretion in mice. The ^99mTc-labeled PL-PEG-GONRs demonstrated a unique biodistribution pattern of rapid accumulation in and excretion from the liver. Moreover, we determined that the PL-PEG-GNORs were excreted from the body through the renal route in urine, and we used hematological analysis to show that the PL-PEG-GNORs were not toxic in vivo. Furthermore, doxorubicin-loaded PL-PEG-GONRs had IC₅₀ values for chemo-photothermal therapy toward U87 glioma cells that were 6.7-fold lower than the IC₅₀ values in traditional chemotherapy. With these advantages, PL-PEG-GONRs could be used as drug nanocarriers to develop an efficient cancer-therapy strategy that would not only improve the efficacy of the therapy, but would also reduce the risk of side effects of the nanocarrier in the body.

Original language	English
Pages (from-to)	83-95
Number of pages	13
Journal	Carbon
Volume	74
DOIs	https://doi.org/10.1016/j.carbon.2014.03.007
Publication status	Published - 2014 Aug

All Science Journal Classification (ASJC) codes

General Chemistry
General Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.carbon.2014.03.007

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@article{962e81f4dad94a01a5eba44bce4364cd,

title = "Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy",

abstract = "To use graphene oxide nanoribbons (GONRs) in combination with chemo-photothermal therapy, we modified GONRs with phospholipid-polyethylene glycol (PL-PEG) to prepare PEGylated GONRs (PL-PEG-GONRs), followed by investigation of the short-term in vivo biodistribution of 99mTc- labeled PL-PEG-GONRs and their excretion in mice. The 99mTc-labeled PL-PEG-GONRs demonstrated a unique biodistribution pattern of rapid accumulation in and excretion from the liver. Moreover, we determined that the PL-PEG-GNORs were excreted from the body through the renal route in urine, and we used hematological analysis to show that the PL-PEG-GNORs were not toxic in vivo. Furthermore, doxorubicin-loaded PL-PEG-GONRs had IC50 values for chemo-photothermal therapy toward U87 glioma cells that were 6.7-fold lower than the IC50 values in traditional chemotherapy. With these advantages, PL-PEG-GONRs could be used as drug nanocarriers to develop an efficient cancer-therapy strategy that would not only improve the efficacy of the therapy, but would also reduce the risk of side effects of the nanocarrier in the body.",

author = "Lu, {Yu Jen} and Lin, {Chih Wen} and Yang, {Hung Wei} and Lin, {Kun Ju} and Wey, {Shiaw Pyng} and Sun, {Chia Liang} and Wei, {Kuo Chen} and Yen, {Tzu Chen} and Lin, {Ching I.} and Ma, {Chen Chi M.} and Chen, {Jyh Ping}",

note = "Funding Information: The authors thank the Chang Gung Memorial Hospital ( CMRPD2B0071 and CMRPG3B0141 ) and National Tsing Hua University ( 102N2024E1 and 102N2772E1 ) for financial supports. The technical supports from the Microscopy Core Laboratory and Animal Molecular Imaging Center of Chang Gung Memorial Hospital on TEM, confocal microscopy and SPECT/CT tomography are also gratefully acknowledged.",

year = "2014",

month = aug,

doi = "10.1016/j.carbon.2014.03.007",

language = "English",

volume = "74",

pages = "83--95",

journal = "Carbon",

issn = "0008-6223",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy

AU - Lu, Yu Jen

AU - Lin, Chih Wen

AU - Yang, Hung Wei

AU - Lin, Kun Ju

AU - Wey, Shiaw Pyng

AU - Sun, Chia Liang

AU - Wei, Kuo Chen

AU - Yen, Tzu Chen

AU - Lin, Ching I.

AU - Ma, Chen Chi M.

AU - Chen, Jyh Ping

N1 - Funding Information: The authors thank the Chang Gung Memorial Hospital ( CMRPD2B0071 and CMRPG3B0141 ) and National Tsing Hua University ( 102N2024E1 and 102N2772E1 ) for financial supports. The technical supports from the Microscopy Core Laboratory and Animal Molecular Imaging Center of Chang Gung Memorial Hospital on TEM, confocal microscopy and SPECT/CT tomography are also gratefully acknowledged.

PY - 2014/8

Y1 - 2014/8

N2 - To use graphene oxide nanoribbons (GONRs) in combination with chemo-photothermal therapy, we modified GONRs with phospholipid-polyethylene glycol (PL-PEG) to prepare PEGylated GONRs (PL-PEG-GONRs), followed by investigation of the short-term in vivo biodistribution of 99mTc- labeled PL-PEG-GONRs and their excretion in mice. The 99mTc-labeled PL-PEG-GONRs demonstrated a unique biodistribution pattern of rapid accumulation in and excretion from the liver. Moreover, we determined that the PL-PEG-GNORs were excreted from the body through the renal route in urine, and we used hematological analysis to show that the PL-PEG-GNORs were not toxic in vivo. Furthermore, doxorubicin-loaded PL-PEG-GONRs had IC50 values for chemo-photothermal therapy toward U87 glioma cells that were 6.7-fold lower than the IC50 values in traditional chemotherapy. With these advantages, PL-PEG-GONRs could be used as drug nanocarriers to develop an efficient cancer-therapy strategy that would not only improve the efficacy of the therapy, but would also reduce the risk of side effects of the nanocarrier in the body.

AB - To use graphene oxide nanoribbons (GONRs) in combination with chemo-photothermal therapy, we modified GONRs with phospholipid-polyethylene glycol (PL-PEG) to prepare PEGylated GONRs (PL-PEG-GONRs), followed by investigation of the short-term in vivo biodistribution of 99mTc- labeled PL-PEG-GONRs and their excretion in mice. The 99mTc-labeled PL-PEG-GONRs demonstrated a unique biodistribution pattern of rapid accumulation in and excretion from the liver. Moreover, we determined that the PL-PEG-GNORs were excreted from the body through the renal route in urine, and we used hematological analysis to show that the PL-PEG-GNORs were not toxic in vivo. Furthermore, doxorubicin-loaded PL-PEG-GONRs had IC50 values for chemo-photothermal therapy toward U87 glioma cells that were 6.7-fold lower than the IC50 values in traditional chemotherapy. With these advantages, PL-PEG-GONRs could be used as drug nanocarriers to develop an efficient cancer-therapy strategy that would not only improve the efficacy of the therapy, but would also reduce the risk of side effects of the nanocarrier in the body.

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SP - 83

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JO - Carbon

JF - Carbon

ER -

Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy

Abstract

All Science Journal Classification (ASJC) codes

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