Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer

Chou Yuan Ko; Tian Huei Chu; Ching Cheng Hsu; Hsin Pao Chen; Shih Chung Huang; Chen Lin Chang; Shiow Jyu Tzou; Tung Yuan Chen; Chia Chen Lin; Pei Chun Shih; Chung Hsien Lin; Chuan Fa Chang; Yung Kuo Lee

doi:10.3390/jpm12030401

Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer

Chou Yuan Ko, Tian Huei Chu, Ching Cheng Hsu, Hsin Pao Chen, Shih Chung Huang, Chen Lin Chang, Shiow Jyu Tzou, Tung Yuan Chen, Chia Chen Lin, Pei Chun Shih, Chung Hsien Lin, Chuan Fa Chang, Yung Kuo Lee

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7 Citations (Scopus)

Abstract

Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltrans-ferases causing aberrant sialylation is associated with the progression of colon cancer. However, among the ST8- sialyltransferases, the role of ST8SIA6 in colon cancer remains poorly understood. In this study, we explored the involvement of ST8SIA6 in colon cancer using multiple gene data-bases. The relationship between ST8SIA6 expression and tumor stages/grades was investigated by UALCAN analysis, and Kaplan–Meier Plotter analysis was used to analyze the expression of ST8SIA6 on the survival outcome of colon cancer patients. Moreover, the biological functions of ST8SIA6 in colon cancer were explored using LinkedOmics and cancer cell metabolism gene DB. Finally, TIMER and TISMO analyses were used to delineate ST8SIA6 levels in tumor immunity and immunotherapy responses, respectively. ST8SIA6 downregulation was associated with an advanced stage and poorly differentiated grade; however, ST8SIA6 expression did not affect the survival outcomes in patients with colon cancer. Gene ontology analysis suggested that ST8SIA6 par-ticipates in cell surface adhesion, angiogenesis, and membrane vesicle trafficking. In addition, ST8SIA6 levels affected immunocyte infiltration and immunotherapy responses in colon cancer. Collectively, these results suggest that ST8SIA6 may serve as a novel therapeutic target towards personalized medicine for colon cancer.

Original language	English
Article number	401
Journal	Journal of Personalized Medicine
Volume	12
Issue number	3
DOIs	https://doi.org/10.3390/jpm12030401
Publication status	Published - 2022 Mar

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)

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10.3390/jpm12030401

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@article{415ed50528d14b95b00324688defed84,

title = "Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer",

abstract = "Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltrans-ferases causing aberrant sialylation is associated with the progression of colon cancer. However, among the ST8- sialyltransferases, the role of ST8SIA6 in colon cancer remains poorly understood. In this study, we explored the involvement of ST8SIA6 in colon cancer using multiple gene data-bases. The relationship between ST8SIA6 expression and tumor stages/grades was investigated by UALCAN analysis, and Kaplan–Meier Plotter analysis was used to analyze the expression of ST8SIA6 on the survival outcome of colon cancer patients. Moreover, the biological functions of ST8SIA6 in colon cancer were explored using LinkedOmics and cancer cell metabolism gene DB. Finally, TIMER and TISMO analyses were used to delineate ST8SIA6 levels in tumor immunity and immunotherapy responses, respectively. ST8SIA6 downregulation was associated with an advanced stage and poorly differentiated grade; however, ST8SIA6 expression did not affect the survival outcomes in patients with colon cancer. Gene ontology analysis suggested that ST8SIA6 par-ticipates in cell surface adhesion, angiogenesis, and membrane vesicle trafficking. In addition, ST8SIA6 levels affected immunocyte infiltration and immunotherapy responses in colon cancer. Collectively, these results suggest that ST8SIA6 may serve as a novel therapeutic target towards personalized medicine for colon cancer.",

author = "Ko, {Chou Yuan} and Chu, {Tian Huei} and Hsu, {Ching Cheng} and Chen, {Hsin Pao} and Huang, {Shih Chung} and Chang, {Chen Lin} and Tzou, {Shiow Jyu} and Chen, {Tung Yuan} and Lin, {Chia Chen} and Shih, {Pei Chun} and Lin, {Chung Hsien} and Chang, {Chuan Fa} and Lee, {Yung Kuo}",

note = "Funding Information: Acknowledgments: We are grateful for the funding support from Kaohsiung Armed Forces General Hospital. We would like to acknowledge Pei‐Hsuan Wu, Yi‐Ting Wu, and Shieh Yueh‐Yuan for their excellent technical support at Laboratory of Research and Medical Education and Research Center, Kaohsiung Armed Forces General Hospital. Funding Information: Funding: This research and APC were funded by Kaohsiung Armed Forces General Hospital, grant number KAFGH_D_111049; and the Ministry of Science and Technology, Taiwan, grant numbers 107‐2314‐B‐650‐013‐, 108‐2314‐B‐650‐010‐, and 109‐2327‐B‐006‐009‐. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = mar,

doi = "10.3390/jpm12030401",

language = "English",

volume = "12",

journal = "Journal of Personalized Medicine",

issn = "2075-4426",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

TY - JOUR

T1 - Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer

AU - Ko, Chou Yuan

AU - Chu, Tian Huei

AU - Hsu, Ching Cheng

AU - Chen, Hsin Pao

AU - Huang, Shih Chung

AU - Chang, Chen Lin

AU - Tzou, Shiow Jyu

AU - Chen, Tung Yuan

AU - Lin, Chia Chen

AU - Shih, Pei Chun

AU - Lin, Chung Hsien

AU - Chang, Chuan Fa

AU - Lee, Yung Kuo

N1 - Funding Information: Acknowledgments: We are grateful for the funding support from Kaohsiung Armed Forces General Hospital. We would like to acknowledge Pei‐Hsuan Wu, Yi‐Ting Wu, and Shieh Yueh‐Yuan for their excellent technical support at Laboratory of Research and Medical Education and Research Center, Kaohsiung Armed Forces General Hospital. Funding Information: Funding: This research and APC were funded by Kaohsiung Armed Forces General Hospital, grant number KAFGH_D_111049; and the Ministry of Science and Technology, Taiwan, grant numbers 107‐2314‐B‐650‐013‐, 108‐2314‐B‐650‐010‐, and 109‐2327‐B‐006‐009‐. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/3

Y1 - 2022/3

N2 - Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltrans-ferases causing aberrant sialylation is associated with the progression of colon cancer. However, among the ST8- sialyltransferases, the role of ST8SIA6 in colon cancer remains poorly understood. In this study, we explored the involvement of ST8SIA6 in colon cancer using multiple gene data-bases. The relationship between ST8SIA6 expression and tumor stages/grades was investigated by UALCAN analysis, and Kaplan–Meier Plotter analysis was used to analyze the expression of ST8SIA6 on the survival outcome of colon cancer patients. Moreover, the biological functions of ST8SIA6 in colon cancer were explored using LinkedOmics and cancer cell metabolism gene DB. Finally, TIMER and TISMO analyses were used to delineate ST8SIA6 levels in tumor immunity and immunotherapy responses, respectively. ST8SIA6 downregulation was associated with an advanced stage and poorly differentiated grade; however, ST8SIA6 expression did not affect the survival outcomes in patients with colon cancer. Gene ontology analysis suggested that ST8SIA6 par-ticipates in cell surface adhesion, angiogenesis, and membrane vesicle trafficking. In addition, ST8SIA6 levels affected immunocyte infiltration and immunotherapy responses in colon cancer. Collectively, these results suggest that ST8SIA6 may serve as a novel therapeutic target towards personalized medicine for colon cancer.

AB - Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltrans-ferases causing aberrant sialylation is associated with the progression of colon cancer. However, among the ST8- sialyltransferases, the role of ST8SIA6 in colon cancer remains poorly understood. In this study, we explored the involvement of ST8SIA6 in colon cancer using multiple gene data-bases. The relationship between ST8SIA6 expression and tumor stages/grades was investigated by UALCAN analysis, and Kaplan–Meier Plotter analysis was used to analyze the expression of ST8SIA6 on the survival outcome of colon cancer patients. Moreover, the biological functions of ST8SIA6 in colon cancer were explored using LinkedOmics and cancer cell metabolism gene DB. Finally, TIMER and TISMO analyses were used to delineate ST8SIA6 levels in tumor immunity and immunotherapy responses, respectively. ST8SIA6 downregulation was associated with an advanced stage and poorly differentiated grade; however, ST8SIA6 expression did not affect the survival outcomes in patients with colon cancer. Gene ontology analysis suggested that ST8SIA6 par-ticipates in cell surface adhesion, angiogenesis, and membrane vesicle trafficking. In addition, ST8SIA6 levels affected immunocyte infiltration and immunotherapy responses in colon cancer. Collectively, these results suggest that ST8SIA6 may serve as a novel therapeutic target towards personalized medicine for colon cancer.

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U2 - 10.3390/jpm12030401

DO - 10.3390/jpm12030401

M3 - Article

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VL - 12

JO - Journal of Personalized Medicine

JF - Journal of Personalized Medicine

IS - 3

M1 - 401

ER -

Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer

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