TY - JOUR
T1 - Biologically active constituents from the fruiting body of Taiwanofungus camphoratus
AU - Shi, Li Shian
AU - Chao, Chih Hua
AU - Shen, De Yang
AU - Chan, Hsiu Hui
AU - Chen, Chou Hsiung
AU - Liao, Yu Ren
AU - Wu, Shwu Jen
AU - Leu, Yann Lii
AU - Shen, Yuh Chiang
AU - Kuo, Yao Haur
AU - Lee, E. Jian
AU - Qian, Keduo
AU - Wu, Tian Shung
AU - Lee, Kuo Hsiung
N1 - Funding Information:
The authors acknowledge the financial support from the National Science Council, Taiwan, Republic of China and Dr. Tun-Tschu Chang (Division of Forest Protection, Taiwan Forestry Research Institute, Taipei, Taiwan) for his identification of T. camphoratus. Thanks are also due to the partial support from NIH grant CA-17625 awarded to K.-H.L.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Five new benzenoids, benzocamphorins A-E (1-5), and 10 recently isolated triterpenoids, camphoratins A-J (16-25), together with 23 known compounds including seven benzenoids (6-12), three lignans (13-15), and 13 triterpenoids (26-38) were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis. Selected compounds were examined for cytotoxic and anti-inflammatory activities. Compounds 9 and 21 showed moderate cytotoxicity against MCF-7 and Hep2 cell lines with ED 50 values of 3.4 and 3.0 μg/mL, respectively. Compounds 21, 25, 26, 29-31, 33, and 36 demonstrated potent anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 2.5, 1.6, 3.6, 0.6, 4.1, 4.2, 2.5, and 1.5 μM, respectively, which were better than those of the nonspecific nitric oxide synthase (NOS) inhibitor N-nitro-l-arginine methyl ester (l-NAME) (IC 50: 25.8 μM). These results may substantiate the use of T. camphoratus in traditional Chinese medicine (TCM) for the treatment of inflammation and cancer-related diseases. The newly discovered compounds deserve further development as anti-inflammatory candidates.
AB - Five new benzenoids, benzocamphorins A-E (1-5), and 10 recently isolated triterpenoids, camphoratins A-J (16-25), together with 23 known compounds including seven benzenoids (6-12), three lignans (13-15), and 13 triterpenoids (26-38) were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis. Selected compounds were examined for cytotoxic and anti-inflammatory activities. Compounds 9 and 21 showed moderate cytotoxicity against MCF-7 and Hep2 cell lines with ED 50 values of 3.4 and 3.0 μg/mL, respectively. Compounds 21, 25, 26, 29-31, 33, and 36 demonstrated potent anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 2.5, 1.6, 3.6, 0.6, 4.1, 4.2, 2.5, and 1.5 μM, respectively, which were better than those of the nonspecific nitric oxide synthase (NOS) inhibitor N-nitro-l-arginine methyl ester (l-NAME) (IC 50: 25.8 μM). These results may substantiate the use of T. camphoratus in traditional Chinese medicine (TCM) for the treatment of inflammation and cancer-related diseases. The newly discovered compounds deserve further development as anti-inflammatory candidates.
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U2 - 10.1016/j.bmc.2010.10.032
DO - 10.1016/j.bmc.2010.10.032
M3 - Article
C2 - 21115251
AN - SCOPUS:78650718362
SN - 0968-0896
VL - 19
SP - 677
EP - 683
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 1
ER -