Biomarkers of severe dengue disease - A review

Daisy Vanitha John, Yee Shin Lin, Guey Chuen Perng

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The early prediction of severe dengue in patients without any warning signs who may later develop severe DHF is very important to choose appropriate intensive supportive therapy since available vaccines for immunization are yet to be approved. Severe dengue responses include T and B cell activation and apoptosis, cytokine storm, hematologic disorders and complement activation. Cytokines, complement and other unidentified factors may transiently act on the endothelium and alter normal fluid barrier function of the endothelial cells and cause plasma leakage. In this review, the host factors such as activated immune and endothelial cells and their products which can be utilized as biomarkers for severe dengue disease are discussed.

Original languageEnglish
Article number191
JournalJournal of biomedical science
Volume22
Issue number1
DOIs
Publication statusPublished - 2015 Oct 14

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Severe Dengue
Endothelial cells
Biomarkers
Chemical activation
Cytokines
Immunization
Viruses
Vaccines
Cells
Apoptosis
Plasmas
Fluids
Endothelial Cells
Asymptomatic Diseases
Dengue Virus
Dengue
Complement Activation
Virus Diseases
Endothelium
B-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

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abstract = "Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The early prediction of severe dengue in patients without any warning signs who may later develop severe DHF is very important to choose appropriate intensive supportive therapy since available vaccines for immunization are yet to be approved. Severe dengue responses include T and B cell activation and apoptosis, cytokine storm, hematologic disorders and complement activation. Cytokines, complement and other unidentified factors may transiently act on the endothelium and alter normal fluid barrier function of the endothelial cells and cause plasma leakage. In this review, the host factors such as activated immune and endothelial cells and their products which can be utilized as biomarkers for severe dengue disease are discussed.",
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Biomarkers of severe dengue disease - A review. / John, Daisy Vanitha; Lin, Yee Shin; Perng, Guey Chuen.

In: Journal of biomedical science, Vol. 22, No. 1, 191, 14.10.2015.

Research output: Contribution to journalReview article

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