Background: Polyhydroxybutyrate (PHB), an important member of the family of polyhydroxyalkanoates (PHAs), is a biodegradable thermoplastic synthesized by numerous microorganisms under different cultivation conditions. Results: A simple dynamic model for producing PHB in a fed-batch reactor is presented. The kinetic model accuracy is quantified by the specific error measures. The dynamic manipulation scheme with prescribed stepwise changes is used to improve PHB productivity. A multi-objective optimization algorithm is used to determine the optimal feeding strategy. Conclusion: Reduced kinetic models in a mixed culture cultivation process for PHB production are successfully verified. An optimization-based feeding strategy with stepwise changes has been derived and successfully validated.
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)
- Renewable Energy, Sustainability and the Environment
- Fuel Technology
- Waste Management and Disposal
- Organic Chemistry
- Inorganic Chemistry