Biopolymer production in a fed-batch reactor using optimal feeding strategies

Song Yi Lai, Po Chih Kuo, Wei Wu, Ming Feng Jang, Yi Shyong Chou

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background: Polyhydroxybutyrate (PHB), an important member of the family of polyhydroxyalkanoates (PHAs), is a biodegradable thermoplastic synthesized by numerous microorganisms under different cultivation conditions. Results: A simple dynamic model for producing PHB in a fed-batch reactor is presented. The kinetic model accuracy is quantified by the specific error measures. The dynamic manipulation scheme with prescribed stepwise changes is used to improve PHB productivity. A multi-objective optimization algorithm is used to determine the optimal feeding strategy. Conclusion: Reduced kinetic models in a mixed culture cultivation process for PHB production are successfully verified. An optimization-based feeding strategy with stepwise changes has been derived and successfully validated.

Original languageEnglish
Pages (from-to)2054-2061
Number of pages8
JournalJournal of Chemical Technology and Biotechnology
Issue number11
Publication statusPublished - 2013 Nov 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment
  • Fuel Technology
  • Waste Management and Disposal
  • Pollution
  • Organic Chemistry
  • Inorganic Chemistry


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