Biopreparation of an anti-inflammatory agent, diarctigenin, from arctiin isolated from Arctium lappa by Rhizoctonia solani AG-4

Ping-Chung Kuo, Zi Yu Chen, Miao Fan Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the preliminary screening for the plant-derived pesticides against Rhizoctonia solani Kühn AG-4 (RS AG-4), the indicator compounds arctiin (1) and arctigenin (2) in methanol extracts of Arctium lappa L. were consumed and transformed to other compounds. Thus, in the present study RS AG-4 was used as a biocatalyst and the biotransformation of arctiin (1) was investigated. Conversion of arctiin (1) to arctigenin (2) was achieved by the enzymatic hydrolysis of sugar moiety. In addition, an anti-inflammatory lignan dimer reported from the Arctium species, diarctigenin (3) was afforded in good yields. The HPLC monitoring of the biotransformation process indicated the possible mechanism. It would be an excellent method to produce large scale of diarctigenin (3) for the successive medicinal examinations.

Original languageEnglish
Pages (from-to)6955-6958
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number50
DOIs
Publication statusPublished - 2013 Dec 11

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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