TY - JOUR
T1 - Bladder cancer in Taiwan
T2 - Relationship to trihalomethane concentrations present in drinking-water supplies
AU - Chang, Chih Ching
AU - Ho, Shu Chen
AU - Wang, Li Yu
AU - Yang, Chun Yuh
N1 - Funding Information:
Received 30 December 2006; accepted 20 February 2007. This study was partly supported by a grant from the National Science Council, Executive Yuan, Taiwan (NSC-95-2331-B-037-006). Address correspondence to Chun-Yuh Yang, PhD, MPH, Faculty of Public Health, College of Health Sciences, Kaohsiung Medical University, 100 Shih-Chuan 1st RD, Kaohsiung, Taiwan 80708. E-mail: [email protected] DBP exposure. The initial studies, which determined DBP water concentrations and recorded death certificate data, demonstrated evidence of a link between chlorinated drinking water consumption and bladder cancer (Kuzma et al., 1977; Cantor et al., 1978; Page et al., 1976; Bean et al., 1982; Gottlieb et al., 1982; Zierler et al., 1988). Recently, Villanueva et al. (2003) found an odds ratio (OR) of 1.4 (95% CI = 1.2–1.7) for bladder cancer in association with long-term consumption of chlorinated water in a meta-analysis of 6 case-control (Cantor et al., 1987, 1998; McGeehin et al., 1993; King & Marrett, 1996; Koivusalo et al., 1998; Vena et al., 1993) and 2 cohort studies (Wilkins & Comstock, 1981; Doyle et al., 1997). More recently, Villanueva et al. (2004) pooled the primary data from 6 case-control studies (Cantor et al., 1998; Cordier et al., 1993; King and Marrett, 1996; Koivusalo et al., 1998; Lynch et al., 1989) using THM as a marker for the total mixture of DBP and reported a significant increased risk of bladder cancer in association with exposure to a THM at a level of more than 50 μg/L (OR = 1.31, 95% CI = 1.12–1.54).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/1
Y1 - 2007/1
N2 - The objective of this study was to evaluate whether exposure to disinfection by-products (DBP) is associated with bladder cancer. A matched case-control study was used to investigate the relationship between the risk of death from bladder cancer and exposure to total trihalomethanes (TTHM) in drinking water in 65 municipalities in Taiwan. All bladder cancer deaths of the 65 municipalities from 1996 through 2005 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to the cases by gender, year of birth,and year of death. Each matched control was selected randomly from the set of possible controls for each cancer case. Data on TTHM levels in drinking water in study municipalities were collected from the Taiwan Environmental Protection Administration. The municipality of residence for cancer cases and controls was assumed to be the source of the subject's TTHM exposure via drinking water. The adjusted odds ratios for bladder cancer death for those with high TTHM concentrations in their drinking water were 1.8 (1.18-2.74) and 2.11 (1.43-3.11) compared to the lowest group. The results of this study show that there was a significant positive correlation between the concentration of TTHM in drinking water and risk of death from bladder cancer.
AB - The objective of this study was to evaluate whether exposure to disinfection by-products (DBP) is associated with bladder cancer. A matched case-control study was used to investigate the relationship between the risk of death from bladder cancer and exposure to total trihalomethanes (TTHM) in drinking water in 65 municipalities in Taiwan. All bladder cancer deaths of the 65 municipalities from 1996 through 2005 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to the cases by gender, year of birth,and year of death. Each matched control was selected randomly from the set of possible controls for each cancer case. Data on TTHM levels in drinking water in study municipalities were collected from the Taiwan Environmental Protection Administration. The municipality of residence for cancer cases and controls was assumed to be the source of the subject's TTHM exposure via drinking water. The adjusted odds ratios for bladder cancer death for those with high TTHM concentrations in their drinking water were 1.8 (1.18-2.74) and 2.11 (1.43-3.11) compared to the lowest group. The results of this study show that there was a significant positive correlation between the concentration of TTHM in drinking water and risk of death from bladder cancer.
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U2 - 10.1080/15287390701459031
DO - 10.1080/15287390701459031
M3 - Article
C2 - 17885932
AN - SCOPUS:34548837228
SN - 1528-7394
VL - 70
SP - 1752
EP - 1757
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 20
ER -
