TY - JOUR
T1 - Blood group AB is associated with increased risk for severe dengue disease in secondary infections
AU - Kalayanarooj, Siripen
AU - Gibbons, Robert V.
AU - Vaughn, David
AU - Green, Sharone
AU - Nisalak, Ananda
AU - Jarman, Richard G.
AU - Mammen, Mammen P.
AU - Perng, Guey Chuen
N1 - Funding Information:
Received 28 September 2006; accepted 13 November 2006; electronically published 23 February 2007. Potential conflicts of interest: none reported. Presented in part: 55th meeting of the American Society of Tropical Medical and Hygiene, Atlanta, Georgia, 11–16 November 2006 (abstract 1010). Financial support: National Institutes of Health (grant P01 AI1034533). a S.K. and R.V.G. contributed equally to this work. Reprints or correspondence: Dr. Guey-Chuen Perng, Dept. of Virology, USAMC-AFRIMS, APO AP 96546 ([email protected]).
PY - 2007/4/1
Y1 - 2007/4/1
N2 - Why certain individuals progress to severe dengue disease is unknown. In this study, blood groups associated with dengue disease were investigated. ABO phenotypes were identified by use of serum from 399 patients with dengue-virus infection who participated in a cohort study. ABO blood-group frequencies were similar in primary versus secondary dengue-virus infections. However, in secondary infection, individuals with blood group AB were likely to have dengue hemorrhagic fever grade 3 than either grades 1 and 2 combined (corrected P value, <.0001; odds ratio, 0.097 [95% confidence interval, 0.03-0.33]) or dengue fever (corrected P value, <.0001; odds ratio, 0.119 [95% confidence interval, 0.04-0.37]). To our knowledge, this is the first report demonstrating an association between ABO blood group and the severity of dengue disease.
AB - Why certain individuals progress to severe dengue disease is unknown. In this study, blood groups associated with dengue disease were investigated. ABO phenotypes were identified by use of serum from 399 patients with dengue-virus infection who participated in a cohort study. ABO blood-group frequencies were similar in primary versus secondary dengue-virus infections. However, in secondary infection, individuals with blood group AB were likely to have dengue hemorrhagic fever grade 3 than either grades 1 and 2 combined (corrected P value, <.0001; odds ratio, 0.097 [95% confidence interval, 0.03-0.33]) or dengue fever (corrected P value, <.0001; odds ratio, 0.119 [95% confidence interval, 0.04-0.37]). To our knowledge, this is the first report demonstrating an association between ABO blood group and the severity of dengue disease.
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U2 - 10.1086/512244
DO - 10.1086/512244
M3 - Article
C2 - 17330792
AN - SCOPUS:33947381055
SN - 0022-1899
VL - 195
SP - 1014
EP - 1017
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -