Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Aaron Broege, Lan Pham, Eric D. Jensen, Ann Emery, Tsang-Hai Huang, Melissa Stemig, Hideyuki Beppu, Anna Petryk, Michael O'Connor, Kim Mansky, Raj Gopalakrishnan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

Original languageEnglish
Pages (from-to)37230-37240
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
Publication statusPublished - 2013 Dec 27

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Bone Morphogenetic Proteins
Mitogen-Activated Protein Kinases
Osteogenesis
Bone
Bone Remodeling
RANK Ligand
Osteoclasts
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Broege, Aaron ; Pham, Lan ; Jensen, Eric D. ; Emery, Ann ; Huang, Tsang-Hai ; Stemig, Melissa ; Beppu, Hideyuki ; Petryk, Anna ; O'Connor, Michael ; Mansky, Kim ; Gopalakrishnan, Raj. / Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 52. pp. 37230-37240.
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abstract = "Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.",
author = "Aaron Broege and Lan Pham and Jensen, {Eric D.} and Ann Emery and Tsang-Hai Huang and Melissa Stemig and Hideyuki Beppu and Anna Petryk and Michael O'Connor and Kim Mansky and Raj Gopalakrishnan",
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Broege, A, Pham, L, Jensen, ED, Emery, A, Huang, T-H, Stemig, M, Beppu, H, Petryk, A, O'Connor, M, Mansky, K & Gopalakrishnan, R 2013, 'Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis', Journal of Biological Chemistry, vol. 288, no. 52, pp. 37230-37240. https://doi.org/10.1074/jbc.M113.496950

Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis. / Broege, Aaron; Pham, Lan; Jensen, Eric D.; Emery, Ann; Huang, Tsang-Hai; Stemig, Melissa; Beppu, Hideyuki; Petryk, Anna; O'Connor, Michael; Mansky, Kim; Gopalakrishnan, Raj.

In: Journal of Biological Chemistry, Vol. 288, No. 52, 27.12.2013, p. 37230-37240.

Research output: Contribution to journalArticle

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T1 - Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

AU - Broege, Aaron

AU - Pham, Lan

AU - Jensen, Eric D.

AU - Emery, Ann

AU - Huang, Tsang-Hai

AU - Stemig, Melissa

AU - Beppu, Hideyuki

AU - Petryk, Anna

AU - O'Connor, Michael

AU - Mansky, Kim

AU - Gopalakrishnan, Raj

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

AB - Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

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