Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Aaron Broege, Lan Pham, Eric D. Jensen, Ann Emery, Tsang Hai Huang, Melissa Stemig, Hideyuki Beppu, Anna Petryk, Michael O'Connor, Kim Mansky, Raj Gopalakrishnan

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

Original languageEnglish
Pages (from-to)37230-37240
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
Publication statusPublished - 2013 Dec 27

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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