Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Aaron Broege; Lan Pham; Eric D. Jensen; Ann Emery; Tsang Hai Huang; Melissa Stemig; Hideyuki Beppu; Anna Petryk; Michael O'Connor; Kim Mansky; Raj Gopalakrishnan

doi:10.1074/jbc.M113.496950

Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Aaron Broege, Lan Pham, Eric D. Jensen, Ann Emery, Tsang Hai Huang, Melissa Stemig, Hideyuki Beppu, Anna Petryk, Michael O'Connor, Kim Mansky, Raj Gopalakrishnan

Institute of Physical Education, Health & Leisure Studies

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

Original language	English
Pages (from-to)	37230-37240
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M113.496950
Publication status	Published - 2013 Dec 27

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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Broege, A., Pham, L., Jensen, E. D., Emery, A., Huang, T. H., Stemig, M., Beppu, H., Petryk, A., O'Connor, M., Mansky, K., & Gopalakrishnan, R. (2013). Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis. Journal of Biological Chemistry, 288(52), 37230-37240. https://doi.org/10.1074/jbc.M113.496950

Broege, Aaron ; Pham, Lan ; Jensen, Eric D. ; Emery, Ann ; Huang, Tsang Hai ; Stemig, Melissa ; Beppu, Hideyuki ; Petryk, Anna ; O'Connor, Michael ; Mansky, Kim ; Gopalakrishnan, Raj. / Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 52. pp. 37230-37240.

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title = "Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis",

abstract = "Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.",

author = "Aaron Broege and Lan Pham and Jensen, {Eric D.} and Ann Emery and Huang, {Tsang Hai} and Melissa Stemig and Hideyuki Beppu and Anna Petryk and Michael O'Connor and Kim Mansky and Raj Gopalakrishnan",

year = "2013",

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doi = "10.1074/jbc.M113.496950",

language = "English",

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Broege, A, Pham, L, Jensen, ED, Emery, A, Huang, TH, Stemig, M, Beppu, H, Petryk, A, O'Connor, M, Mansky, K & Gopalakrishnan, R 2013, 'Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis', Journal of Biological Chemistry, vol. 288, no. 52, pp. 37230-37240. https://doi.org/10.1074/jbc.M113.496950

Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis. / Broege, Aaron; Pham, Lan; Jensen, Eric D.; Emery, Ann; Huang, Tsang Hai; Stemig, Melissa; Beppu, Hideyuki; Petryk, Anna; O'Connor, Michael; Mansky, Kim; Gopalakrishnan, Raj.

In: Journal of Biological Chemistry, Vol. 288, No. 52, 27.12.2013, p. 37230-37240.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

AU - Broege, Aaron

AU - Pham, Lan

AU - Jensen, Eric D.

AU - Emery, Ann

AU - Huang, Tsang Hai

AU - Stemig, Melissa

AU - Beppu, Hideyuki

AU - Petryk, Anna

AU - O'Connor, Michael

AU - Mansky, Kim

AU - Gopalakrishnan, Raj

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

AB - Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

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JO - Journal of Biological Chemistry

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Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

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