Abstract
Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 37230-37240 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 52 |
| DOIs | |
| Publication status | Published - 2013 Dec 27 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
}
Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis. / Broege, Aaron; Pham, Lan; Jensen, Eric D.; Emery, Ann; Huang, Tsang-Hai; Stemig, Melissa; Beppu, Hideyuki; Petryk, Anna; O'Connor, Michael; Mansky, Kim; Gopalakrishnan, Raj.
In: Journal of Biological Chemistry, Vol. 288, No. 52, 27.12.2013, p. 37230-37240.Research output: Contribution to journal › Article
TY - JOUR
T1 - Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis
AU - Broege, Aaron
AU - Pham, Lan
AU - Jensen, Eric D.
AU - Emery, Ann
AU - Huang, Tsang-Hai
AU - Stemig, Melissa
AU - Beppu, Hideyuki
AU - Petryk, Anna
AU - O'Connor, Michael
AU - Mansky, Kim
AU - Gopalakrishnan, Raj
PY - 2013/12/27
Y1 - 2013/12/27
N2 - Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.
AB - Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.
UR - http://www.scopus.com/inward/record.url?scp=84891472124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891472124&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.496950
DO - 10.1074/jbc.M113.496950
M3 - Article
VL - 288
SP - 37230
EP - 37240
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 52
ER -