Both diabetes and fetuin-A are independently associated with increased risk of arterial stiffness

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Abstract

Background: Arterial stiffness is a functional assessment of vascular damage caused by cardiovascular disease (CVD) risk factors. Fetuin-A is associated with subclinical CVD and incident or fatal CVD, with some modification of its effect occurring with the presence of diabetes. We investigated the impact of different glycemic statuses and serum fetuin-A levels on arterial stiffness. Methods: A total of 312 age- and sex-matched subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes (NDD) were recruited. Serum fetuin-A levels were measured, and arterial stiffness was assessed by brachial-ankle pulse-wave velocity (baPWV). Results: We found that the mean values of baPWV were 1533 ± 338, 1518 ± 353, 1589 ± 307, and 1690 ± 414. cm/s, and fetuin-A levels were 298 ± 69, 313 ± 67, 330 ± 86, and 342 ± 93. μg/ml, in subjects with NGT, IFG, IGT, and NDD, respectively (both p < 0.001, test for trend). NDD subjects had significantly higher baPWV and fetuin-A levels than those with NGT. Multiple linear regression analysis showed that age, fetuin-A, diabetes, hypertension, and hypertriglyceridemia are independently associated factors of baPWV after adjusting for cardiometabolic risk factors, HOMA-IR, and adiponectin. Conclusion: Both diabetes and fetuin-A levels are independently associated with arterial stiffness. Fetuin-A may further aggravate increased arterial stiffness in diabetes.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalClinica Chimica Acta
Volume445
DOIs
Publication statusPublished - 2015 May 1

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alpha-2-HS-Glycoprotein
Vascular Stiffness
Medical problems
Stiffness
Pulse Wave Analysis
Glucose Intolerance
Glucose
Ankle
Arm
Cardiovascular Diseases
Fasting
Functional assessment
Hypertriglyceridemia
Adiponectin
Serum
Linear regression
Regression analysis
Blood Vessels
Linear Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

@article{9b221f0a52ba4cbb9dfb36b95ed9b208,
title = "Both diabetes and fetuin-A are independently associated with increased risk of arterial stiffness",
abstract = "Background: Arterial stiffness is a functional assessment of vascular damage caused by cardiovascular disease (CVD) risk factors. Fetuin-A is associated with subclinical CVD and incident or fatal CVD, with some modification of its effect occurring with the presence of diabetes. We investigated the impact of different glycemic statuses and serum fetuin-A levels on arterial stiffness. Methods: A total of 312 age- and sex-matched subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes (NDD) were recruited. Serum fetuin-A levels were measured, and arterial stiffness was assessed by brachial-ankle pulse-wave velocity (baPWV). Results: We found that the mean values of baPWV were 1533 ± 338, 1518 ± 353, 1589 ± 307, and 1690 ± 414. cm/s, and fetuin-A levels were 298 ± 69, 313 ± 67, 330 ± 86, and 342 ± 93. μg/ml, in subjects with NGT, IFG, IGT, and NDD, respectively (both p < 0.001, test for trend). NDD subjects had significantly higher baPWV and fetuin-A levels than those with NGT. Multiple linear regression analysis showed that age, fetuin-A, diabetes, hypertension, and hypertriglyceridemia are independently associated factors of baPWV after adjusting for cardiometabolic risk factors, HOMA-IR, and adiponectin. Conclusion: Both diabetes and fetuin-A levels are independently associated with arterial stiffness. Fetuin-A may further aggravate increased arterial stiffness in diabetes.",
author = "Ou, {Horng Yih} and Lu, {Feng Hwa} and Wu, {Hung Tsung} and Hung, {Hao Chang} and Wu, {Jin Shang} and Yang, {Yi Ching} and Chang, {Chih Jen}",
year = "2015",
month = "5",
day = "1",
doi = "10.1016/j.cca.2015.03.030",
language = "English",
volume = "445",
pages = "133--138",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
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}

TY - JOUR

T1 - Both diabetes and fetuin-A are independently associated with increased risk of arterial stiffness

AU - Ou, Horng Yih

AU - Lu, Feng Hwa

AU - Wu, Hung Tsung

AU - Hung, Hao Chang

AU - Wu, Jin Shang

AU - Yang, Yi Ching

AU - Chang, Chih Jen

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: Arterial stiffness is a functional assessment of vascular damage caused by cardiovascular disease (CVD) risk factors. Fetuin-A is associated with subclinical CVD and incident or fatal CVD, with some modification of its effect occurring with the presence of diabetes. We investigated the impact of different glycemic statuses and serum fetuin-A levels on arterial stiffness. Methods: A total of 312 age- and sex-matched subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes (NDD) were recruited. Serum fetuin-A levels were measured, and arterial stiffness was assessed by brachial-ankle pulse-wave velocity (baPWV). Results: We found that the mean values of baPWV were 1533 ± 338, 1518 ± 353, 1589 ± 307, and 1690 ± 414. cm/s, and fetuin-A levels were 298 ± 69, 313 ± 67, 330 ± 86, and 342 ± 93. μg/ml, in subjects with NGT, IFG, IGT, and NDD, respectively (both p < 0.001, test for trend). NDD subjects had significantly higher baPWV and fetuin-A levels than those with NGT. Multiple linear regression analysis showed that age, fetuin-A, diabetes, hypertension, and hypertriglyceridemia are independently associated factors of baPWV after adjusting for cardiometabolic risk factors, HOMA-IR, and adiponectin. Conclusion: Both diabetes and fetuin-A levels are independently associated with arterial stiffness. Fetuin-A may further aggravate increased arterial stiffness in diabetes.

AB - Background: Arterial stiffness is a functional assessment of vascular damage caused by cardiovascular disease (CVD) risk factors. Fetuin-A is associated with subclinical CVD and incident or fatal CVD, with some modification of its effect occurring with the presence of diabetes. We investigated the impact of different glycemic statuses and serum fetuin-A levels on arterial stiffness. Methods: A total of 312 age- and sex-matched subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes (NDD) were recruited. Serum fetuin-A levels were measured, and arterial stiffness was assessed by brachial-ankle pulse-wave velocity (baPWV). Results: We found that the mean values of baPWV were 1533 ± 338, 1518 ± 353, 1589 ± 307, and 1690 ± 414. cm/s, and fetuin-A levels were 298 ± 69, 313 ± 67, 330 ± 86, and 342 ± 93. μg/ml, in subjects with NGT, IFG, IGT, and NDD, respectively (both p < 0.001, test for trend). NDD subjects had significantly higher baPWV and fetuin-A levels than those with NGT. Multiple linear regression analysis showed that age, fetuin-A, diabetes, hypertension, and hypertriglyceridemia are independently associated factors of baPWV after adjusting for cardiometabolic risk factors, HOMA-IR, and adiponectin. Conclusion: Both diabetes and fetuin-A levels are independently associated with arterial stiffness. Fetuin-A may further aggravate increased arterial stiffness in diabetes.

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DO - 10.1016/j.cca.2015.03.030

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VL - 445

SP - 133

EP - 138

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

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