TY - JOUR
T1 - Brain cancer associated with environmental lead exposure
T2 - Evidence from implementation of a National Petrol-Lead Phase-Out Program (PLPOP) in Taiwan between 1979 and 2007
AU - Wu, Wei Te
AU - Lin, Yu Jen
AU - Liou, Saou Hsing
AU - Yang, Chun Yuh
AU - Cheng, Kuang Fu
AU - Tsai, Perng Jy
AU - Wu, Trong Neng
N1 - Funding Information:
This study received support from China Medical University, Taichung, Taiwan ( CMU98-C-01 ).
PY - 2012/4
Y1 - 2012/4
N2 - Background and objective: In 1981, a Petrol-Lead Phase-Out Program (PLPOP) was launched in Taiwan for the abatement of environmental lead emissions. The present study was intended to examine whether the high Petrol-Lead Emission Areas (PLEA) would result in an increase in the incidence rate of brain cancer based on a national data bank. Methods: The national brain cancer incidence data was obtained from the Taiwan National Cancer Registry. Age standardized incidence rates were calculated based on the 2000 WHO world standard population, and gasoline consumption data was obtained from the Bureau of Energy. The differences in the trend tests for age-standardized incidence rates of brain cancer between high, median, low, and small PLEA were analyzed. Results: A significant increase was found from small to high PLEA in age-standardized incidence rates of brain cancer. By taking six possible confounders into account, the age-standardized incidence rates for brain cancer were highly correlated with the median and high PLEA by reference to the small PLEA. Conclusion: After being adjusted for a number of relevant confounders, it could be concluded that high PLEA might result in an increase in the incidence rate of brain cancer resulting from high lead exposures.
AB - Background and objective: In 1981, a Petrol-Lead Phase-Out Program (PLPOP) was launched in Taiwan for the abatement of environmental lead emissions. The present study was intended to examine whether the high Petrol-Lead Emission Areas (PLEA) would result in an increase in the incidence rate of brain cancer based on a national data bank. Methods: The national brain cancer incidence data was obtained from the Taiwan National Cancer Registry. Age standardized incidence rates were calculated based on the 2000 WHO world standard population, and gasoline consumption data was obtained from the Bureau of Energy. The differences in the trend tests for age-standardized incidence rates of brain cancer between high, median, low, and small PLEA were analyzed. Results: A significant increase was found from small to high PLEA in age-standardized incidence rates of brain cancer. By taking six possible confounders into account, the age-standardized incidence rates for brain cancer were highly correlated with the median and high PLEA by reference to the small PLEA. Conclusion: After being adjusted for a number of relevant confounders, it could be concluded that high PLEA might result in an increase in the incidence rate of brain cancer resulting from high lead exposures.
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U2 - 10.1016/j.envint.2011.06.009
DO - 10.1016/j.envint.2011.06.009
M3 - Article
C2 - 21821291
AN - SCOPUS:84856225056
VL - 40
SP - 97
EP - 101
JO - Environmental International
JF - Environmental International
SN - 0160-4120
IS - 1
ER -