Abstract
Backgrounds: To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD). Methods: We recruited 117 MDD patients who were randomized to fluoxetine or venlafaxine treatment and 106 controls. The association between genotypes and percentage changes in the Hamilton Rating Scale for Depression (HAM-D) scores over time was analyzed by repeated-measures ANOVA. The antidepressants were included in the model as covariates. Results: The frequency of the BDNF Val66Met polymorphisms was not significantly different between patient and control groups. Significantly changes in HAM-D scores were noted after 2 and 4 weeks of venlafaxine treatment among different genotypes. Conclusions: Results suggest antidepressants acting through different mechanisms may affect the BDNF Val66Met polymorphism differently.
Original language | English |
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Pages (from-to) | 430-435 |
Number of pages | 6 |
Journal | Journal of Affective Disorders |
Volume | 126 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 Nov |
All Science Journal Classification (ASJC) codes
- Clinical Psychology
- Psychiatry and Mental health