Brain region-dependent increases in β-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits

C. W. Wu, Pao-Chi Liao, C. Lin, C. J. Kuo, S. T. Chen, H. I. Chen, Yu-Min Kuo

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Recent studies indicate a possible link between serum cholesterol level, β-amyloid (Aβ) peptide concentrations, and the incidence of Alzheimer's disease (AD). In the present report, the effects of dietary cholesterol on Aβ and apolipoprotein E (APOE) levels in several brain regions were examined using diet-induced hypercholesterolemic rabbits as the animal model. Increased dietary cholesterol levels increased Aβ concentrations in temporal cortex (p = 0.02). A similar trend was observed in the frontal cortex (p = 0.06), yet not in the cerebellum. Interestingly, the regional levels of Aβ in the hypercholesterolemic rabbit paralleled the amyloid pathology observed in AD brain. Elevated APOE levels were also noticed in temporal (p < 0.01) and frontal (p < 0.01) cortices, but not in cerebellum, in the rabbit fed with cholesterol-abundant diet. These results suggest that high serum cholesterol levels could induce the elevation of brain APOE, which may play a role in aggravating the Aβ accumulation.

Original languageEnglish
Pages (from-to)641-649
Number of pages9
JournalJournal of Neural Transmission
Volume110
Issue number6
DOIs
Publication statusPublished - 2003 Jun 1

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Brain region-dependent increases in β-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits'. Together they form a unique fingerprint.

Cite this