Briarenols W-Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (Kükenthal, 1908)

You Ying Chen, Yi Lin Zhang, Gene Hsiang Lee, Lun Kelvin Tsou, Mingzi M. Zhang, Hsing Pang Hsieh, Jih Jung Chen, Chou Yuan Ko, Zhi Hong Wen, Ping Jyun Sung

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Abstract

Briareum stechei is proven to be a rich source of 3,8-cyclized cembranoids (briarane) with a bicyclo[8.4.0] carbon core. In the present study, four previously unreported briaranes, briarenols W-Z (1-4), along with solenolide A (5), briarenolide M (6), briaexcavatolide F (7), and brianolide (8), were isolated and characterized through spectroscopic analysis, and the absolute configuration of 8 was corroborated by a single-crystal x-ray diffraction analysis. Briaranes 2 and 5 were found to induce significant inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophage cells by enhancing the expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins.

Original languageEnglish
JournalMarine Drugs
Volume19
Issue number2
DOIs
Publication statusPublished - 2021 Jan 31

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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