@article{3c6e697ead6040188f25f8fdbada70cf,
title = "Briarenols W–Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (K{\"u}kenthal, 1908)",
abstract = "Briareum stechei is proven to be a rich source of 3,8-cyclized cembranoids (briarane) with a bicyclo[8.4.0] carbon core. In the present study, four previously unreported briaranes, briarenols W–Z (1–4), along with solenolide A (5), briarenolide M (6), briaexcavatolide F (7), and brianolide (8), were isolated and characterized through spectroscopic analysis, and the absolute configuration of 8 was corroborated by a single-crystal x-ray diffraction analysis. Briaranes 2 and 5 were found to induce significant inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophage cells by enhancing the expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins.",
author = "Chen, {You Ying} and Zhang, {Yi Lin} and Lee, {Gene Hsiang} and Tsou, {Lun Kelvin} and Zhang, {Mingzi M.} and Hsieh, {Hsing Pang} and Chen, {Jih Jung} and Ko, {Chou Yuan} and Wen, {Zhi Hong} and Sung, {Ping Jyun}",
note = "Funding Information: Funding: The research was founded by the Ministry of Science and Technology of Taiwan (MOST 107-2320-B-291-001-MY3, 108-2638-B-400-001-MY2, and 109-2320-B-291-001-MY3). Funding Information: Acknowledgments: This work was mainly supported by grants from the National Museum of Marine Biology and Aquarium; the Ministry of Science and Technology, Taiwan, awarded to H.-P.H and P.-J.S.; the Center of Applied Nanomedicine, National Cheng Kung University; and the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan, awarded to H.-P.H. All funding is gratefully acknowledged. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = feb,
doi = "10.3390/MD19020077",
language = "English",
volume = "19",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",
}