Calcium alginate microcapsule generation on a microfluidic system fabricated using the optical disk process

Keng Shiang Huang, Ming Kai Liu, Chun Han Wu, Yu Tang Yen, Yu Cheng Lin

Research output: Contribution to journalArticle

40 Citations (Scopus)


This paper describes the generation of monodisperse calcium alginate (Ca-alginate) microcapsules on a microfluidic platform using the commercial optical disk process. Our strategy is based on combining the rapid injection molding process for a cross-junction microchannel with the sheath focusing effect to form uniform water-in-oil (w/o) emulsions. These emulsions, consisting of 1.5% (w/v) sodium alginate (Na-alginate), are then dripped into a solution containing 20% (w/v) calcium chloride (CaCl2) creating Ca-alginate microparticles in an efficient manner. This paper demonstrates that the size of Ca-alginate microparticles can be controlled from 20 νm to 50 νm in diameter with a variation of less than 10%, simply by altering the relative sheath/sample flow rate ratio. Experimental data show that for a given fixed dispersed phase flow (sample flow), the emulsion size decreases as the average flow rate of the continuous phase flow (sheath flow) increases. The proposed microfluidic platform is capable of generating relatively uniform emulsions and has the advantages of active control of the emulsion diameter, a simple and low cost process and a high throughput.

Original languageEnglish
Article number003
Pages (from-to)1428-1434
Number of pages7
JournalJournal of Micromechanics and Microengineering
Issue number8
Publication statusPublished - 2007 Aug 1

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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