Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

Shwu Jen Wu, Yann Lii Leu, Chou Hsiung Chen, Chih Hua Chao, De Yang Shen, Hsiu Hui Chan, E. Jian Lee, Tian Shung Wu, Yea Hwey Wang, Yuh Chiang Shen, Keduo Qian, Kenneth F. Bastow, Kuo Hsiung Lee

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Abstract

Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC50 values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC50 values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor Nω-nitro-l-arginine methyl ester.

Original languageEnglish
Pages (from-to)1756-1762
Number of pages7
JournalJournal of Natural Products
Volume73
Issue number11
DOIs
Publication statusPublished - 2010 Nov 29

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Wu, S. J., Leu, Y. L., Chen, C. H., Chao, C. H., Shen, D. Y., Chan, H. H., Lee, E. J., Wu, T. S., Wang, Y. H., Shen, Y. C., Qian, K., Bastow, K. F., & Lee, K. H. (2010). Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus. Journal of Natural Products, 73(11), 1756-1762. https://doi.org/10.1021/np1002143