Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida

Shou Fang Wu, Pei Wen Hsieh, Chin Chung Wu, Chia Lin Lee, Shu Li Chen, Chi Yu Lu, Tian Shung Wu, Fang Rong Chang, Yang Chang Wu

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26 Citations (Scopus)

Abstract

Two new alkaloids, 9-methoxy-18,19-dehydrocamptothecin (1) and 5-hydroxymappicine-20-O-β-glucopyranoside (2a/2b as a racemic mixture), together with nine known compounds: camptothecin (3), 9-methoxy-camptothecin (4), 5-hydroxycamptothecin (5a/5b racemic mixture), 5-hydroxy-9- methoxycamptothecin (6a/6b racemic mixture), diosmetin (7), apigenin (8), apigenin-7-O-glucopyranoside (9), rosin (cinnamyl-O-β-D-glucopyranoside) (10) and amarantholidoside IV (11) were isolated from the immature seeds of Nothapodytes foetida (Wight) Sleumer. The structures were elucidated by spectroscopic analyses. In the present research, compounds 1, 3, 4, 5a/5b and 6a/6b, also showed in vitro cytotoxicity against six cancer cell lines (HepG2, Hep3B, MDA-MB-231, MCF-7, A549, and Ca9-22). Among them, compound 1 exhibited significant cytotoxicity against these cancer cell lines, with IC50 of 0.24-6.57 μM. Furthermore, HPLC profiles were developed for qualitative and quantitative analysis of these active constituents in different parts of this plant, including mature and immature seeds, leaves, stems and roots. The results revealed that compounds 3 and 4 have the highest concentrations, which are found in the roots part of the plant.

Original languageEnglish
Pages (from-to)1361-1371
Number of pages11
JournalMolecules
Volume13
Issue number6
DOIs
Publication statusPublished - 2008 Jun

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Wu, S. F., Hsieh, P. W., Wu, C. C., Lee, C. L., Chen, S. L., Lu, C. Y., Wu, T. S., Chang, F. R., & Wu, Y. C. (2008). Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida. Molecules, 13(6), 1361-1371. https://doi.org/10.3390/molecules13061361