TY - JOUR
T1 - Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus
AU - Young, Chainllie
AU - Gean, Po Wu
AU - Wu, Shang Peng
AU - Lin, Chih Hung
AU - Shen, Yu Zen
N1 - Funding Information:
This study was supported by the National Science Council of Taiwan to Yu-Zen Shen (NSC86-2314-B002-126).
PY - 1998/5/15
Y1 - 1998/5/15
N2 - The effects of docosahexaenoic acid (DHA) on low-frequency stimulation (LFS)-induced long-term depression (LTD) were investigated in the CA 1 subfield of rat hippocampal slices. LTD was routinely produced by LFS of 900 pulses at 1 Hz. The field excitatory postsynaptic potential (fEPSP) 40 min after LFS was 59 ± 4% (n = 18) of baseline response. However, in experiments from 18 neurons pretreated with DHA (50 μM), fEPSP returned to baseline levels within 20 min after LFS in eight cells and was slightly potentiated in three cells. Only in seven cells was LTD induced. The effect of DHA on LTD was concentration dependent. The slopes of fEPSP 40 min after LFS were 67 ± 4% (n = 6), 72 ± 7% (n = 7) and 80 ± 5% (n = 18) of baseline response, with pretreatment of 1, 10 and 50 μM DHA, respectively. The blockade of LTD induction suggests that DHA may play a role in learning and memory.
AB - The effects of docosahexaenoic acid (DHA) on low-frequency stimulation (LFS)-induced long-term depression (LTD) were investigated in the CA 1 subfield of rat hippocampal slices. LTD was routinely produced by LFS of 900 pulses at 1 Hz. The field excitatory postsynaptic potential (fEPSP) 40 min after LFS was 59 ± 4% (n = 18) of baseline response. However, in experiments from 18 neurons pretreated with DHA (50 μM), fEPSP returned to baseline levels within 20 min after LFS in eight cells and was slightly potentiated in three cells. Only in seven cells was LTD induced. The effect of DHA on LTD was concentration dependent. The slopes of fEPSP 40 min after LFS were 67 ± 4% (n = 6), 72 ± 7% (n = 7) and 80 ± 5% (n = 18) of baseline response, with pretreatment of 1, 10 and 50 μM DHA, respectively. The blockade of LTD induction suggests that DHA may play a role in learning and memory.
UR - https://www.scopus.com/pages/publications/0032524915
UR - https://www.scopus.com/pages/publications/0032524915#tab=citedBy
U2 - 10.1016/S0304-3940(98)00272-9
DO - 10.1016/S0304-3940(98)00272-9
M3 - Article
C2 - 9655627
AN - SCOPUS:0032524915
SN - 0304-3940
VL - 247
SP - 198
EP - 200
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2-3
ER -