Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery

Ronnie H. Fang, Che Ming J. Hu, Brian T. Luk, Weiwei Gao, Jonathan A. Copp, Yiyin Tai, Derek E. O'Connor, Liangfang Zhang

Research output: Contribution to journalArticlepeer-review

476 Citations (Scopus)

Abstract

Cell-derived nanoparticles have been garnering increased attention due to their ability to mimic many of the natural properties displayed by their source cells. This top-down engineering approach can be applied toward the development of novel therapeutic strategies owing to the unique interactions enabled through the retention of complex antigenic information. Herein, we report on the biological functionalization of polymeric nanoparticles with a layer of membrane coating derived from cancer cells. The resulting core-shell nanostructures, which carry the full array of cancer cell membrane antigens, offer a robust platform with applicability toward multiple modes of anticancer therapy. We demonstrate that by coupling the particles with an immunological adjuvant, the resulting formulation can be used to promote a tumor-specific immune response for use in vaccine applications. Moreover, we show that by taking advantage of the inherent homotypic binding phenomenon frequently observed among tumor cells the membrane functionalization allows for a unique cancer targeting strategy that can be utilized for drug delivery applications.

Original languageEnglish
Pages (from-to)2181-2188
Number of pages8
JournalNano letters
Volume14
Issue number4
DOIs
Publication statusPublished - 2014 Apr 9

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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