TY - JOUR
T1 - Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs
AU - Wu, Ya Na
AU - Chen, Dong Hwang
AU - Shi, Xian Yu
AU - Lian, Chiao Ching
AU - Wang, Ting Yu
AU - Yeh, Chen Sheng
AU - Ratinac, Kyle R.
AU - Thordarson, Pall
AU - Braet, Filip
AU - Shieh, Dar Bin
N1 - Funding Information:
Conflict of Interest: This work was supported by grant NSC-98-3114-M-006-002 and 98-2218-E-006-008-MY3 from the National Science Council, of Taiwan , and by Linkage Infrastructure, Equipment, and Facilities grant LE0775598 from the Australian Research Council (ARC) . Ya-Na Wu is an recipient of a University of Sydney International scholarship.
PY - 2011/8
Y1 - 2011/8
N2 - Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 μg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no significant difference in the NP uptake between cancer and control cells, and cytotoxicity resulted primarily from the iron core, before oxidation, rather than from the Fe ions released from the core. In contrast with magnetic NPs that usually serve as drug carriers, diagnostic probes or hyperthermia media, the iron, before oxidation, in the NPs selectively suppressed cancer cell growth and left healthy control cells unaffected in vitro and in vivo. This novel nanomaterial holds great promise as a therapeutic tool in nanomedicine.
AB - Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 μg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no significant difference in the NP uptake between cancer and control cells, and cytotoxicity resulted primarily from the iron core, before oxidation, rather than from the Fe ions released from the core. In contrast with magnetic NPs that usually serve as drug carriers, diagnostic probes or hyperthermia media, the iron, before oxidation, in the NPs selectively suppressed cancer cell growth and left healthy control cells unaffected in vitro and in vivo. This novel nanomaterial holds great promise as a therapeutic tool in nanomedicine.
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U2 - 10.1016/j.nano.2011.01.002
DO - 10.1016/j.nano.2011.01.002
M3 - Article
C2 - 21272668
AN - SCOPUS:79960708216
SN - 1549-9634
VL - 7
SP - 420
EP - 427
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 4
ER -
