Cancer immunotherapy: Silencing intracellular negative immune regulators of dendritic cells

Yao Hua Liu, I. Jeng Yeh, Ming Derg Lai, Kuan Ting Liu, Po Lin Kuo, Meng Chi Yen

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Dendritic cells (DCs) are capable of activating adaptive immune responses, or inducing immune suppression or tolerance. In the tumor microenvironment, the function of DCs is polarized into immune suppression that attenuates the effect of T cells, promoting differentiation of regulatory T cells and supporting tumor progression. Therefore, blocking negative immune regulators in DCs is considered a strategy of cancer immunotherapy. Antibodies can target molecules on the cell surface, but not intracellular molecules of DCs. The delivery of short-hairpin RNAs (shRNA) and small-interfering RNAs (siRNA) should be a strategy to silence specific intracellular targets in DCs. This review provides an overview of the known negative immune regulators of DCs. Moreover, a combination of shRNA/siRNA and DC vaccines, DNA vaccines in animal models, and clinical trials are also discussed.

Original languageEnglish
Article number108
JournalCancers
Volume11
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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