Candida peritonitis due to peptic ulcer perforation: Incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B

Sai Cheong Lee, Chang Phone Fung, Huang Yang Chen, Chiung Tsung Li, Shyh Chuan Jwo, Yi Ben Hung, Lai Chu See, How Chin Liao, Song Seng Loke, Feng Lin Wang, Jenq-Chang Lee

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Sixty-two cases of peritonitis due to peptic ulcer perforation were diagnosed between January 2000 and December 2000. Of these 62 cases, 23 isolates of Candida in 23 cases (CP) were cultured from peritoneal fluid. Cultures of peritoneal fluid of 10 (BP) of the remaining 39 cases was positive for bacteria only. Cultures of peritoneal fluid of the remaining 29 cases was negative. Comparison of CP, BP and culture-negative cases did not reveal any significant risk factor. Of the 23 Candida isolates, the Candida species and 48-h MICs of fluconazole and amphotericin B (mean, range ug/ml) were C. albicans 18 (0.688, 0.125-1.0; 0.297, 0.031-0.5), C. glabrata 3 (0.542, 0.125-1.0; 0.25, 0.125-0.5), C. tropicalis 1 (0.25; 0.5), C. intermedia 1 (1.0; 0.125) respectively. Mortality rates of CP, BP and culture-negative peritonitis due to infection were 5/23(21.7%), 0/10 and 1/29(3.4%) respectively. Without effective antifungal therapy, the mortality rate of CP was not low.

Original languageEnglish
Article number10895
Pages (from-to)23-27
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume44
Issue number1
DOIs
Publication statusPublished - 2002 Jan 1

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Peptic Ulcer Perforation
Fluconazole
Ascitic Fluid
Amphotericin B
Peritonitis
Candida
Incidence
Mortality
Bacteria
Infection
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Lee, Sai Cheong ; Fung, Chang Phone ; Chen, Huang Yang ; Li, Chiung Tsung ; Jwo, Shyh Chuan ; Hung, Yi Ben ; See, Lai Chu ; Liao, How Chin ; Loke, Song Seng ; Wang, Feng Lin ; Lee, Jenq-Chang. / Candida peritonitis due to peptic ulcer perforation : Incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B. In: Diagnostic Microbiology and Infectious Disease. 2002 ; Vol. 44, No. 1. pp. 23-27.
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abstract = "Sixty-two cases of peritonitis due to peptic ulcer perforation were diagnosed between January 2000 and December 2000. Of these 62 cases, 23 isolates of Candida in 23 cases (CP) were cultured from peritoneal fluid. Cultures of peritoneal fluid of 10 (BP) of the remaining 39 cases was positive for bacteria only. Cultures of peritoneal fluid of the remaining 29 cases was negative. Comparison of CP, BP and culture-negative cases did not reveal any significant risk factor. Of the 23 Candida isolates, the Candida species and 48-h MICs of fluconazole and amphotericin B (mean, range ug/ml) were C. albicans 18 (0.688, 0.125-1.0; 0.297, 0.031-0.5), C. glabrata 3 (0.542, 0.125-1.0; 0.25, 0.125-0.5), C. tropicalis 1 (0.25; 0.5), C. intermedia 1 (1.0; 0.125) respectively. Mortality rates of CP, BP and culture-negative peritonitis due to infection were 5/23(21.7{\%}), 0/10 and 1/29(3.4{\%}) respectively. Without effective antifungal therapy, the mortality rate of CP was not low.",
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Candida peritonitis due to peptic ulcer perforation : Incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B. / Lee, Sai Cheong; Fung, Chang Phone; Chen, Huang Yang; Li, Chiung Tsung; Jwo, Shyh Chuan; Hung, Yi Ben; See, Lai Chu; Liao, How Chin; Loke, Song Seng; Wang, Feng Lin; Lee, Jenq-Chang.

In: Diagnostic Microbiology and Infectious Disease, Vol. 44, No. 1, 10895, 01.01.2002, p. 23-27.

Research output: Contribution to journalArticle

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T1 - Candida peritonitis due to peptic ulcer perforation

T2 - Incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B

AU - Lee, Sai Cheong

AU - Fung, Chang Phone

AU - Chen, Huang Yang

AU - Li, Chiung Tsung

AU - Jwo, Shyh Chuan

AU - Hung, Yi Ben

AU - See, Lai Chu

AU - Liao, How Chin

AU - Loke, Song Seng

AU - Wang, Feng Lin

AU - Lee, Jenq-Chang

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Sixty-two cases of peritonitis due to peptic ulcer perforation were diagnosed between January 2000 and December 2000. Of these 62 cases, 23 isolates of Candida in 23 cases (CP) were cultured from peritoneal fluid. Cultures of peritoneal fluid of 10 (BP) of the remaining 39 cases was positive for bacteria only. Cultures of peritoneal fluid of the remaining 29 cases was negative. Comparison of CP, BP and culture-negative cases did not reveal any significant risk factor. Of the 23 Candida isolates, the Candida species and 48-h MICs of fluconazole and amphotericin B (mean, range ug/ml) were C. albicans 18 (0.688, 0.125-1.0; 0.297, 0.031-0.5), C. glabrata 3 (0.542, 0.125-1.0; 0.25, 0.125-0.5), C. tropicalis 1 (0.25; 0.5), C. intermedia 1 (1.0; 0.125) respectively. Mortality rates of CP, BP and culture-negative peritonitis due to infection were 5/23(21.7%), 0/10 and 1/29(3.4%) respectively. Without effective antifungal therapy, the mortality rate of CP was not low.

AB - Sixty-two cases of peritonitis due to peptic ulcer perforation were diagnosed between January 2000 and December 2000. Of these 62 cases, 23 isolates of Candida in 23 cases (CP) were cultured from peritoneal fluid. Cultures of peritoneal fluid of 10 (BP) of the remaining 39 cases was positive for bacteria only. Cultures of peritoneal fluid of the remaining 29 cases was negative. Comparison of CP, BP and culture-negative cases did not reveal any significant risk factor. Of the 23 Candida isolates, the Candida species and 48-h MICs of fluconazole and amphotericin B (mean, range ug/ml) were C. albicans 18 (0.688, 0.125-1.0; 0.297, 0.031-0.5), C. glabrata 3 (0.542, 0.125-1.0; 0.25, 0.125-0.5), C. tropicalis 1 (0.25; 0.5), C. intermedia 1 (1.0; 0.125) respectively. Mortality rates of CP, BP and culture-negative peritonitis due to infection were 5/23(21.7%), 0/10 and 1/29(3.4%) respectively. Without effective antifungal therapy, the mortality rate of CP was not low.

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